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Has anyone experienced Cassava Sciences’ Simufilam?
Posted: Wednesday, August 4, 2021 2:05 AM
Joined: 8/4/2021
Posts: 1

My mom suffers AD, with a MMSE score of 25, terrible memory, but still ok in everything else.

Last week, i attended in the AAIC Alzheimer’s association international conference virtually to seek help and learn the latest development in the world, found that Cassava sciences showed cognition improvement after 9 month open label test. I am curious to see if anyone here has experience with it, my mom is generally healthy, if it is a good experience, I would like to tell my mom to participate this trial.

Lane Simonian
Posted: Thursday, August 5, 2021 11:37 AM
Joined: 12/12/2011
Posts: 5140

I believe Cassava Sciences is still seeking recruits for their trials.

In an open label trial, most people on simufilam improved in terms of cognition with an average improvement of 3 points at nine months as measured by ADAS-cog scores.  A few critics say the results are not particularly earth shattering since it was an open label trial and the average improvement was only 3 points (although this was higher than the 1.6 points at 6 months).  The drug used to only slightly outperform Aricept at 6 months but now is going up whereas Aricept begins to go down after 6 months.  Only the two large placebo controlled trials will determine whether simufilam is an effective treatment for Alzheimer's disease.

Welcome here and best wishes to you and your mother.

Posted: Monday, January 10, 2022 5:36 PM
Joined: 9/21/2021
Posts: 1

There have been some recent really good reposts about Cassava's drug, Simufilam.

There is a Youtube video by Joe Springer on January 9th 2022 that has a Dr (a friend of the patients not the treating physician) talk about 2 people he knows taking Cassava's drug and how well they have done on it.

Phase 3 clinical trials recently started.  Go to and see if there is a clinical trial site by you.