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CBD for vascular dementia
Jim32
Posted: Monday, August 9, 2021 10:16 PM
Joined: 3/28/2021
Posts: 28


The following website indicates that CBD is good for vascular dementia:

https://www.dementiacarecentral.com/aboutdementia/treating/cbd/

 

Here is a quote from the above website:

Vascular dementia is a general term describing problems with reasoning, planning, judgment, memory and other thought processes caused by brain damage from impaired blood flow to one’s brain. To effectively treat vascular dementia, a 2016 study by the US National Institute of Health (NIH) found that activating CB2 (cannabinoid) receptors in the brain helped recover better blood flow to the brain. Activating the CB2 receptors with CBD has increased brain cell activity and helped reduce brain cell damage commonly associated with vascular dementia.

 

Here is the 2016 study mentioned in the quote:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865067/

 

So, does CBD actually help with vascular dementia? My mother has vascular dementia, and I'm wondering whether CBD will be good for her. 

Some CBD products are in pill form, and other CBD products are in liquid form and have to be inserted under the tongue with a dropper. Unfortunately, my mother sometimes spits out the pill medications that she is given. So, which CBD product(s) would be ideal for my mother? Which specific brand(s)? Would someone who spits out pills also spit out drops inserted with a dropper?

Thanks for any information.

 


Lane Simonian
Posted: Saturday, August 14, 2021 2:39 PM
Joined: 12/12/2011
Posts: 4998


I was hoping someone would come here to answer your questions.  This forum is becoming like a ghost town.  Ten years ago there was a wealth of fascinating treatment options being discussed by some of the smartest people I knew.  Now almost nothing.

I would expect putting drops in a flavored drink might work better than capsules, but I don't know for sure.  High cannabidiol, low THC extracts are usully recommended.

From a larger perspective, much of the damage done to the brain in many forms of dementia, including Alzheimer's disease and vascular dementia, is caused by peroxynitrite.  


Targeting Nitrosative Stress for Neurovascular Protection: New Implications in Brain Diseases


Nitric oxide/peroxynitrite signaling is associated with manifold neurovascular pathogenic cascades that lead to neurodegenerative diseases, including ischemic stroke, Alzheimers disease, and vascular dementia. Considerable evidence suggests that reactive nitrogen species as mediators of nitrosative stress could damage biomolecules and subsequently facilitate the breakdown of the highly-structured cellular machinery. Herein, we focus on nitrosative stress signaling, which is intimately associated with endothelial cell injury and blood-brain barrier damage in stroke and neurodegenerative diseases. Unraveling the detrimental role of nitrosative stress signaling in initiating and driving neurovascular pathogenesis may lead to the development of novel vasoprotective strategies via restorative therapies for brain diseases. 

Several components in marijuana are peroxynitrite scavengers and so it presents a potential way to treat vascular dementa.  

Hopefully someone with direct experience with the use of marijuana for vascular dementia will post her.


Jim32
Posted: Sunday, August 15, 2021 7:02 PM
Joined: 3/28/2021
Posts: 28


Hi, Lane. Thanks for your response.

 

Currently, my mother is in an assisted-living facility with memory care.

 

She has been taking Aricept (one 10-mg pill at night) since early April 2021.

She started taking Alpha GPC in late July 2021. For the first 2 weeks, she took one 300-mg pill (with food) in the morning. Then she started taking one 300-mg pill (with food) in the morning and one 300-mg pill (with food) in the afternoon. Eventually, she will work her way up to two 300-mg pills (with food) in the morning and two 300-mg pills (with food) in the afternoon.

 

If she takes CBD oil, does she have to take that CBD oil in *addition* to the Aricept and the Alpha GPC? Or does she have to discontinue the Aricept and/or the Alpha GPC before taking the CBD oil?

 

 


Lane Simonian
Posted: Tuesday, August 17, 2021 9:51 AM
Joined: 12/12/2011
Posts: 4998


I am not sure how well this has been studied, but I could not find any negative interactions between CBD oil and Alpha GPC and/or Aricept.
Jim32
Posted: Sunday, August 22, 2021 1:35 AM
Joined: 3/28/2021
Posts: 28


It seems that CBD oil's interactions with Aricept and Alpha GPC may be the least of our problems.

 

The following link contains a list of the types of drugs that can negatively interact with CBD oil:

https://cfah.org/cbd-drug-interactions/

 

Three types of drugs on that list are Antipsychotics, Benzodiazepines, and Calcium Channel Blockers.

Currently, my mother takes the following medications at her assisted-living facility with memory care: 

Seroquel (Antipsychotic), for behavioral issues

Ativan (Benzodiazepine), for behavioral issues

Amlodipine (Calcium Channel Blocker), to prevent high blood pressure

a "baby dose" of Morphine, to suppress pain

 

Here is the story about my mother and these medications.

My mother arrived at her current care facility a month ago. During her first few weeks at this facility, she was agitated and was lashing out at caregivers. She was behaving in this way despite having taken Seroquel and Ativan for a while. So, if my mother was behaving poorly even with the Seroquel, then why should she continue to take the Seroquel? Well, according to the facility's director of health services (a nurse), without the Seroquel, my mother's behavior would be even worse.

Also, during my mother's first few weeks at the facility, she supposedly was unable to feed herself.

The facility's overall director, also a nurse, came to the conclusion that my mother was agitated and lashing out at caregivers because my mother was suffering from some type of pain. So, the overall director started my mother on a "baby dose" of morphine. Since my mother started the morphine, she has been very nice to people, and she sometimes feeds herself at mealtime. So, the morphine seems to have "improved" my mother. 

Since the morphine is working so well, does my mother still need Seroquel? Yes, according to the overall director. "Medications work synergistically and stopping and starting regimens that are effective is contraindicated to prevent suffering and a whiplash effect in the patient."

These medical professionals sure love their prescription medications.  

 

Anyway, my mother may have to stop taking the Seroquel, Ativan, Amlodipine, and Morphine, in order to take the CBD oil.

 


Lane Simonian
Posted: Monday, August 23, 2021 9:31 AM
Joined: 12/12/2011
Posts: 4998


CBD oil can reduce anxiety and pain, but I am not sure if it is more or less effective than other medications (on another front, it may reduce the effectiveness of Amlodipine, although I don't think this has been studied in dementia patients).

A similar case can be made for aromatherapy, but it is more from individual case stories.

https://newoldage.blogs.nytimes.com/2011/02/15/clearing-the-fog-in-nursing-homes/

https://www.youtube.com/watch?v=sKN3DGxl06o