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New Alzheimer's Model Derived from Patient's Skin Cells
Posted: Tuesday, July 17, 2012 11:25 PM
Joined: 12/6/2011
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From Alzheimer's Daily News:

(Source: Alzheimer's Assn.) - Researchers presenting at the Alzheimer's Association International Conference reported the creation of a new model of Alzheimer's derived from the skin cells of people with the disease that were reprogrammed into Alzheimer's brain cells.

This new Alzheimer's model may prove to be more accurate than current mouse models of the disease and therefore can be used (a) to generate important new insights into the biology of Alzheimer's and related disorders and (b) for early stage testing of new therapies. "Current animal models of Alzheimer's are highly engineered to express elements of the disease, and, while valuable for research, incompletely represent how the disease forms and progresses in people," said William Thies, PhD.


"In order to develop better therapies and eventually prevent Alzheimer's, we need better, more accurate animal and cellular models of the disease. This newly reported research is a significant step forward in that direction." Most of the current Alzheimer's mouse models incorporate genetic changes found in familial young-onset forms of Alzheimer's. Although these mice have taught us about many valuable aspects of the disease, the hallmark amyloid plaques found in the brains of people with Alzheimer's do not form in the same way as in the brains of mice expressing mutant forms of the most common young-onset Alzheimer's gene, and significant brain cell death does not occur.


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