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Posted: Friday, March 8, 2019 8:18 AM
Joined: 12/4/2011
Posts: 20249
Posted: Saturday, March 9, 2019 5:12 AM
Joined: 8/22/2017
Posts: 531

To jfkox --Thank you for posting this -- my husband did have gingivitis decades ago -- he had gum surgery and became a devoted flosser and brusher etc. Could that have been the cause of his ALZ at 64?  Or was it his type 2 diabetes, which his mother had, but she died in her 90's with no cognitive loss.  But if gum disease is a cause of ALZ, wouldn't many more people have had it over time?  Since baby boomers have probably had the best dental care in history, why would this be happening now?  Longevity uncovering lurking infections?  

So many questions -- given the vagaries of onset and the lack of known causal factors,  it seems that it must be the case that there are multiple causes of ALZ, including, for instance, type 2 diabetes -- but what if it turns out there is one big cause?  The discovery that stomach ulcers were due to h-pylori bacterial infections, rather than stress or other psychological symptoms lurks in my mind.  Will they figure it out in our life time?  We know it is too late for us as ALZ spouses to expect to learn anything, but thank you for posting this.  The mind wonders and waits for an explanation.
Lane Simonian
Posted: Saturday, March 9, 2019 10:24 AM
Joined: 12/12/2011
Posts: 5001

There are indeed likely many causes of Alzheimer's disease.  Gingivitis and high glucose levels are probably two of them.  Others may include high sodium levels, high fructose corn syrup, various environmental toxins, high levels of stress, other bacterial infections, viral infections, and fungal infections.

To go back to one of my favorite quotes:

Dr. Carrasco and his team think a clinical trial of anti-fungal drugs is the next logical step. But there is yet another possibility. In the absence of a definitive ultimate cause, it may be that the symptoms of Alzheimer's disease can arise from many different types of insult to the brain. There have been several papers, says Dr. Le Guillou, that have found correlations between various infectious organisms and Alzheimer's. "It could be like the Mississippi river,' says Dr. Hardy. "You can start in all sorts of places, but eventually you're going to end up in New Orleans." If Alzheimer's is a general response to all sorts of neurological triggers, then it may be that the fungal infections found by Dr. Carrasco are simply one of a long list of causes.

All these risk factors do two things: they increase inflammation in the brain and they oxidize and nitrate key receptors, enzymes, and transport systems in the brain which among other things reduce levels of acetylcholine so that individuals cannot retrieve various types of memories