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Alpha GPC for vascular dementia
Posted: Monday, June 7, 2021 12:06 PM
Joined: 3/28/2021
Posts: 30

There is a news story that says that the Food and Drug Administration (FDA) of the United States has approved a drug called Aducanumab for Alzheimer's. Here is the news story:


In the comments section of this story, someone mentioned a drug called Alpha GPC. Here is the full comment:


Hard to believe that Europe has been using Alpha GPC for Alzheimer patients as a prescription medication, yet our FDA has yet to approve it. It has choline that is found in mother's breast milk to help the brain develop in babies. My spouse has mild dimentia and has been taking it for a year and a half and I haven't noticed any further problems with her memory or cognitive function. There is a chemical within the brain known as acetycholine that the brain uses to transmit information between neurons and receptors. The Choline family of nootropics is a very popular supplement that is designed to help memory and improve cognitive thinking and is a component of acetycholine. When you take Alpha GPC, all of the compounds are separated and synthesized by your body. The acetycholine from the Alpha GPC is stored by the brain and used when needed to enhance memory. As a person ages, the amount of choline in the brain starts to naturally deteriorate. This is what begins to cause memory loss as we get older. This process is accelerated due to conditions such as Alzheimer’s and dementia, which can both be combated by an increase in acetycholine. Alpha GPC helps to not only maintain the proper level of acetycholine the brain needs to function, but offers the brain the ability to store acetycholine and utilize it as needed.


This drug is apparently available in the United States as an over-the-counter supplement.

So, has anyone on this forum tried this drug on themselves or their family members?

Would this drug work on a patient who has vascular dementia?


Posted: Monday, June 14, 2021 10:54 PM
Joined: 3/28/2021
Posts: 30

The following PDF document describes the various studies that have been conducted on Alpha GPC over the years:


Lane Simonian
Posted: Tuesday, June 15, 2021 10:43 AM
Joined: 12/12/2011
Posts: 5088

These results are better than I would have expected.  In Alzheimer's disease, there are problems with the transport of choline, with the enzyme that puts acetylcholine together (choline acetyltransferase), and the release of acetylcholine through muscarinic acetylcholine receptors.  Perhaps this supplement partially leads to the increased production of acetylcholine despite all these problems.  

The one two year study looked at a combination of Alzheimer's disease and vascular dementia so Alpha GPC might help with vascular dementia alone.  

Posted: Tuesday, July 6, 2021 12:46 PM
Joined: 2/26/2016
Posts: 260

There is a good reason why the FDA has not approved this product as a prescription drug. No company has been willing to submit this drug for approval, which would require a FDA clinical trial. Evidentially it is a naturally occurring product. They may be allowed to sell it as a food supplement but they can't legally claim that it can effectively treat any disease.