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Alzheimer's Disease and Cancer
Lane Simonian
Posted: Friday, September 10, 2021 7:51 PM
Joined: 12/12/2011
Posts: 4998


Alzheimer's disease and cancer--two of the most feared diseases of our age--would seem to be opposite diseases.  Alzheimer's disease is cell death without cell growth whereas cancer is cell growth without cell death.  The notion that they are opposite diseases appears to be reinforced by the observation that those with cancer rarely develop Alzheimer's disease and those who develop Alzheimer's disease rarely develop cancer.

But strangely enough, the two diseases may share a common origin: oxidation by either hydrogen peroxide and peroxynitrite and nitration by peroxynitrite.  In Alzheimer's disease, peroxynitrite-mediate nitration prevents the activation of the phosphatidyinositol 3-kinase-Akt pathway, thus preventing the regeneration of neurons.  In cancer oxidation of Pten prevents dephosphorylation removing the brakes on the phosphatidylinositol 3-kinase-Akt growth pathway.  In both cases, DNA damage, inflammation, and the disabling of immune responses due to oxidation and nitration prevents the body (and brain) from being able to fight back.

In theory at least, compounds that limit oxidation and nitration, and partially reverse the multi-faceted damage that they do should help in the treatment of both disease.  For instance, polysaccharides, sapoinins and polyphenols in panax ginseng/Korean red ginseng reduce neuronal cell death while helping promote the regeneration of neurons in Alzheimer's disease, while contributing to the death of cells in cancer.

Improvement of Cognitive Deficit in Alzheimer’s Disease Patients by Long Term Treatment with Korean Red Ginseng

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659550/

 

Ginseng consumption and risk of cancer: A meta-analysis

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005362/

Role of Asian Ginseng in the Prevention and Treatment of Cancer

 https://www.herbalgram.org/resources/herbclip/issues/bin_276/review44095/


Éva1
Posted: Monday, September 13, 2021 12:50 PM
Joined: 9/13/2021
Posts: 1


 Thank You for all the wonderful information. I really appreciate the understanding of this disease. 

Éva1


Lane Simonian
Posted: Monday, September 13, 2021 7:30 PM
Joined: 12/12/2011
Posts: 4998


Thank you very much, Éva.  Welcome here.