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Why Alzheimer's Association Clinical Trials doesn't include Focused Ultrasound, PhotoNeuromodulation /GENUS
HowDoYouDeal
Posted: Monday, July 6, 2020 11:07 AM
Joined: 2/17/2019
Posts: 347


"Our policy, therefore, is to avoid promoting any therapeutic approach that is still under investigation. "
 
 On Thursday, March 7, 2019, 10:12:34 a.m. EST, Science Staff <sciencestaff@alz.org> wrote:
Dear    ***8*" How do you Deal",

Thanks for contacting the Alzheimer’s Association. Recently, there have been some encouraging studies on the use of focused ultrasound (FUS) and light therapy as possible Alzheimer’s disease treatments.

 

  In one such study, a Phase 1 clinical trial, researchers have been examining the safety and tolerability of using FUS to open the blood-brain barrier (BBB) in people with Alzheimer's.

 This trial was inspired by earlier work in animal models—work showing that focused ultrasound could open the BBB and deliver a wide range of drugs to the brain in enhanced concentrations. It also may stimulate an immune response that clears beta-amyloid and tau (two Alzheimer’s-related protein molecules) from the brain.

It is important to note that the Phase 1 trial was very small—less than 10 participants. A larger, Phase 2 trial of FUS therapy has recently begun recruiting participants in West Virginia. If the results of this study are successful, we foresee future testing of focused ultrasound in still larger trials.

However, carrying out Phase 2 and Phase 3 studies to prove the benefits of any therapy is a complex process requiring additional research—and success is not guaranteed.

 

 Our policy, therefore, is to avoid promoting any therapeutic approach that is still under investigation. Instead, we provide news articles about treatment-related clinical trials on our website. You can use our site’s search function to find this information. You might also want to peruse our “funded studies” section at:


This section describes all of the latest research projects funded by our organization.
Thanks again for your query.
Sincerely,
Science Staff
Alzheimer’s Association

HowDoYouDeal
Posted: Monday, July 6, 2020 11:12 AM
Joined: 2/17/2019
Posts: 347


https://health.sunnybrook.ca/research/focused-ultrasound-alzheimers-disease/
Lane Simonian
Posted: Monday, July 6, 2020 1:30 PM
Joined: 12/12/2011
Posts: 4855


I have received a similar response in the past from the Alzheimer's Association to other "alternative" treatments.  The stock response is somewhat disingenious because the Alzheimer's Association tends to either ignore or make it difficult to locate many studies and clinical trials that do not fit their criteria of a "legitimate" study or trial.
HowDoYouDeal
Posted: Monday, July 6, 2020 1:52 PM
Joined: 2/17/2019
Posts: 347


I wrote them back pointing out their website says its dedicated to promoting awareness of the latest Alzheimer's  News, not the latest news they agree with,

 and "the latest research", not the latest research they have funded

and that in a clinical trial, regardless of whether its in Phase 1, Phase 2 or Phase 3, results are never guaranteed.

 Anyone who's been watching the search for an Alzheimer drug knows that all too well!

 -So they just didn't write back. Not Surprised.

 

 

 

 


Lane Simonian
Posted: Monday, July 6, 2020 3:03 PM
Joined: 12/12/2011
Posts: 4855


Your response was perfect.  Sometimes organizations get set in their ways and cannot be budged.  With something like Alzheimer's disease, you have to overturn every promising stone; otherwise things get missed.