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Anyone have experience with Phosphatidylserine and/or Phosphatidic Acid? (Positive results seen in Israeli study.)
Posted: Tuesday, July 31, 2012 1:10 PM
Joined: 12/20/2011
Posts: 217

 Probably many here have heard of and perhaps tried Phosphatidylserine which is supposed to help with memory, cognitive function and AD. 


Recently I learned that some products are combining Phosphatidylserine with another ingredient called Phosphatidic Acid.  The combination supposedly works better than Phosphatidylserine alone. 


Anyone have any experience with these ingredients, or any comments about them, either pro or con? 


I have no experience with these particular products and am not endorsing them, but a few of the products that I think contain both Phosphatidylserine AND Phosphatidic Acid are:

- Lipogen PS Plus
- Memoraid
- MemreePlus
- GCI Nutrients - LipoSerine
(There are other products with very similar or even identical names that may have very different ingredients, so it gets confusing.)


At least some of the supplements combining Phosphatidylserine with Phosphatidic Acid look pretty pricey.  The products with Phosphatidylserine alone seem quite a bit less expensive, and positive results have been seen with Phosphatidylserine alone.


Here's an encouraging study I just came across:



"This double-blind study assessed the influence of plant phosphatidylserine (PS) product on memory and mood in functioning elderly, aged 60-80 years old, and living in the community. Seventy-two subjects, randomly assigned to placebo and therapy groups, were treated for three months with 300 mg. PS daily. Results showed a large and statistically significant positive influence of treatment on both memory and mood, whereas influence of placebo was small and non-significant. This influence was stronger with higher pre-treatment memory scores. Components of memory and cognition that were most improved by the treatment included memorising information, visual memory, and memorising numbers. Mood was also influenced. Winter mood changes ("Winter Blues") did develop in the placebo group but were entirely blocked in those treated with plant PS. 

See the full study (with charts) here: 

WebMD page on Phosphatidylserine:  


Any comments, pro or con, are appreciated.  Thanks. 






Posted: Saturday, August 4, 2012 8:05 PM
Joined: 12/20/2011
Posts: 217

 Another phosphatidylserine study:


2010 Nov;47(3):246-55. Epub 2010 Sep 29

Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints.


Yakult Central Institute for Microbiological Research, 1796 Yaho, Kunitachi, Tokyo 186-8650, Japan.


Soybean-derived phosphatidylserine (Soy-PS) is a phosphatidylserine made from soybean lecithin by enzymatic reaction with L-serine. A double-blind, randomized controlled study was conducted to investigate the effects of Soy-PS on the cognitive functions of the elderly Japanese subjects with memory complaints. Seventy-eight elderly people with mild cognitive impairment (50-69 years old) were randomly allocated to take Soy-PS (100 mg, 300 mg/day) or placebo for 6 months. As a result, there was no difference in blood markers and vital signs during Soy-PS treatment and any side effect caused by Soy-PS treatment was not observed. Neuropsychological test scores were similarly increased in all groups including placebo group. However, in the subjects with relatively low score at baseline, the memory scores in PS treated groups were significantly increased against the baseline, while those of placebo group remained unchanged. And the memory improvements in Soy-PS-treated groups were mostly attributed to the increase in delayed verbal recall, a memory ability attenuated in the earliest stage of dementia. In conclusion, Soy-PS used in this study is considered as safety food ingredient and 6 months of Soy-PS supplementation could improve the memory functions of the elderly with memory complaints.

The full paper: