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Sugary Solution to Alzheimer's
Posted: Wednesday, February 29, 2012 6:02 PM
Joined: 12/6/2011
Posts: 3326

From Alzheimer's Daily News:

(Source: Medical Xpress) - Slowing or preventing the development of Alzheimer's may be as simple as ensuring a brain protein's sugar levels are maintained.

That's the conclusion seven researchers, including David Vocadlo, Canada Research Chair in Chemical Glycobiology. They describe how they've used an inhibitor (Thiamet-G) to stop O-GlcNAcase, a naturally occurring enzyme, from depleting the protein Tau of sugar molecules.

"This work shows targeting the enzyme O-GlcNAcase with inhibitors is a new potential approach to treating Alzheimer's," said Vocadlo. "This is vital since to date there are no treatments to slow its progression.

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