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More on the skin cancer drug reversing amyloid plaques
Posted: Friday, February 10, 2012 11:14 AM
Joined: 12/6/2011
Posts: 3326

From Alzheimer's Daily News:

(Source: Scientific American) - A nearly 13-year-old skin cancer drug rapidly alleviates molecular signs of Alzheimer's and improves brain function, according to the results of a new mouse study being hailed as extremely promising. Early-stage human clinical trials could begin within months.

In the study Case Western Reserve University researchers used mice genetically engineered to exhibit some of the symptoms of Alzheimer's. Most notably, the mice produced amyloid beta peptides - toxic protein fragments that gum up neurons and lead to cell death - and showed signs of forgetfulness.

"We have successfully reversed all of the known pathological features and behavioral deficits found in mouse models of Alzheimer's disease," explained Gary Landreth. "Never before has anyone observed clearance of amyloid plaques with such speed in mouse models."

Other Alzheimer's researchers hail the work. "I think this is extremely promising," said Samuel Gandy, a professor of neurology and psychiatry at Mount Sinai School of Medicine and associate director of the hospital's Alzheimer's Disease Research Center. "One of the drugs that has been on our wish list for 25 years is a drug that would clear existing amyloid deposits."

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Posted: Friday, February 10, 2012 12:18 PM
Joined: 2/10/2012
Posts: 1

has anyone heard or know how to get bexarotene  thanks laha
Lane Simonian
Posted: Friday, February 10, 2012 6:38 PM
Joined: 12/12/2011
Posts: 4854

Here is a cautionary tale about bexarotene and "mice and men." 

I think there is something to be taken away from this research: bexarotene (a retonoid) likely allows for the degradation of amyloid plaques early in Alzheimer's disease, because it inhibits the production of inducible nitric oxide and thus the formation of peroxynitrites.  By nitrating amyloid plaques, peroxynitrites prevent them from being degraded. 


As the disease progresses, one needs compounds that not only inhibit inducible nitric oxide and superoxide anion production, but also scavenge peroxynitrites and reverse part of the damage that they do to the brain.  Fortunately there are many such compounds and each one tested so far in animal models of Alzheimer's disease have prevented and/or ameliorated cognitive decline.  They include rosmarinic acid, alaternin from the Piper Betel, hydroxychavicol from Cassia tora, the marine alga Symphocladia latiuscula, Holy Basil (Ocimum sanctum), SuHeXiang Wan essential oil, and Zataria multiflora Boiss. essential oil.;year=2009;volume=3;issue=1;spage=6;epage=15;aulast=Raghavendra 


I have been able to stop the progression of Alzheimer's disease and partially reverse its course in my mother by using essential oils that are peroxynitrite scavengers (rosemary, sage, oregano, thyme, bay laurel, cinnamon leaf, and orange).  She smells the oils from a bottle for a few seconds each morning. 


As the role of peroxynitrites in Alzheimer's disease becomes better known, likely new peroxynitrite scavengers will emerge for the treatment of the disease. 


daughter taking care of mother
Posted: Saturday, February 11, 2012 9:40 AM
Joined: 12/18/2011
Posts: 315

I have been using a diffuser every day with my mother. In the morning I mix rosemary and orange and in the afternoon lavender and lemon. I may have the orange and lemon reversed. She will seem better sometimes, but lately she thinks she isn't at home or she wants to know where I am and I am standing or sitting nearby. The room has a good smell even if it may not be helping her. I am going to get some of the other essential oils the poster above mentioned and give them a try too.
Lane Simonian
Posted: Saturday, February 11, 2012 11:10 AM
Joined: 12/12/2011
Posts: 4854

It sounds like you are following the Jimbo study, which is good. 

I don't  think it will make a difference as I use orange essential oil in the morning, too, but you might try the lemon in the morning and the orange in the evening, as lemon is held to be more of a stimulant than orange.  The study had a very specific way of delivering the oil and a specific concentration that I am not sure is easy to repeat.  How they decided about that specific concentration I don't know. I use direct inhalation from a bottle, just because it is easier; I am not sure if it is more effective. A trained aromatherapist may be able to help, although the use of aromatherapy to treat Alzheimer's disease is still in an experimental stage.  I feel confident about the oils that I am using, but not about whether a more effective way of delivering them (and in what concentrations if using a diffuser) exists or not.


My mother also used to insist it wasn't her home.  I told her you have been living here for fifty years, which was to no avail. She used to knock on our door in the middle of the night and ask why we haven't left.  She used to ask why her parents were being left out in the cold.


Sometimes she recognizes her home when we come up the driveway.  She no longer asks to leave it and she no longer asks why her parents are being left out in the cold, although she will on much rarer occasions ask where they are.   She sleeps through the night.


Sometimes, she will ask "where's Lane?" And I say, "I am right here."  Sometimes she calls me by name.  I said, "you remembered my name." And she said, "Why, shouldn't I?"  She likes to recite the alphabet and count steps. A few years back she couldn't sleep and I asked why. She said, "I am trying to remember my name." Once I told it to her, she fell asleep.  She can usually give her first and last name when asked now and she can sometimes spell it.


Her ability to answer questions appears to be related to her focus at the time you ask them.  If her mind is on something else, she won't answer them even if you ask several times.  But if her focus is there, you can say something like you scream, I scream, we all scream for...and she will say ice cream.  To me the extent of her attention span seems random, although it may have some relationship to when the oils were given and when they take effect.  On the other hand, she is at certain times able to answer questions she was not able to answer before (like the order of days and months), she is lucid more often, and in an intangible but strangely palatable way, she seems more connected to the world around her (maybe that's what Jimbo and colleagues meant when they said "all [dementia] patients showed improvement in personal orientation related to cognitive function.")


My mother still has Alzheimer's disease.  The improvements she has made are significant, if sometimes seemingly intermittent. Based on personal experience, animal studies, clinical trials, nursing home studies, and my own understanding of the disease, I believe that aromatherapy partially reverses the disease, so that it makes Alzheimer's a chronic rather than a fatal disease. In the process, it gives a person not only a longer life, but a better quality of life.




Lane Simonian
Posted: Saturday, February 11, 2012 11:30 AM
Joined: 12/12/2011
Posts: 4854

I see, you mean that you have the orange and lemon reversed in your mind (which I do, too, when I mention this study), and that you are actually using the lemon in the morning and the orange in the evening.  Sorry about that.


I am quite interested in the Ecumen study which is partly based on the use of aromatherapy.  At least some of the improvements shown in their patients is likely due to the aromatherapy. 


Just for an Alzheimer's patient to able to express what he or she needs and feels may be one of the biggest benefits of aromatherapy. Plus the person's mood improves and they sleep better. 

Posted: Monday, February 13, 2012 8:54 PM
Joined: 1/23/2012
Posts: 2

I'd like to know if knows about or is sponsoring (or plans to sponsor) clinical trials of beraxotine. I looked in the Clinical Trials section of the research part of the site and couldn't find anything currently happening. I understand that this preliminary study has just been published, and these things take time, but I would be very excited to sign my mom up for a trial of this very promising drug.