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Coptidis rhizoma alkaloids for Alzheimer's disease
Lane Simonian
Posted: Friday, March 9, 2012 10:45 AM
Joined: 12/12/2011
Posts: 5107

A number of plants might be useful in the prevention and treatment of Alzheimer's disease (see Myriam's post on Black Cohosh and SunshineFour's post on Ashwagandha, for instance).  The alkaloids from Coptidis rhizoma--a Chinese herb also known as Huang Lian--appear to be particularly promising. 


The authors conclude that due to their role in inhibiting the formation of amyloid plaques and in scavenging peroxynitrites:  "Coptidis rhizoma and the alkaloids contained therein would clearly have beneficial uses in the development of therapeutic and preventive agents for AD and oxidative stress related diseases." It appears that the extract is only made in China (although it can be purchased in the United States) and that these extracts contain mostly berberine which although highly touted may be the least effective of the alkaloids in Coptidis rhizoma.