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Brain Insulin Resistance Contributes to Cognitive Decline in Alzheimer's
Myriam
Posted: Tuesday, March 27, 2012 9:51 PM
Joined: 12/6/2011
Posts: 3326


From Alzheimer's Daily News:


(Source: Penn Medicine) - Insulin resistance in the brain precedes and contributes to cognitive decline above and beyond other known causes of Alzheimer's disease, according to a new study by researchers from the Perelman School of Medicine at the University of Pennsylvania .

Insulin is an important hormone in many bodily functions, including the health of brain cells. The team identified extensive abnormalities in the activity of two major signaling pathways for insulin and insulin-like growth factor in non-diabetic people with Alzheimer's disease. These pathways could be targeted with new or existing medicines to potentially help resensitize the brain to insulin and possibly slow down or even improve cognitive decline.

This is the first study to directly demonstrate that insulin resistance occurs in the brains of people with Alzheimer's disease.

Go to full story: http://www.uphs.upenn.edu