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Cholesterol Drug Shows Benefit in Alzheimer's Animal Study
Myriam
Posted: Wednesday, April 4, 2012 12:53 PM
Joined: 12/6/2011
Posts: 3326


From Alzheimer's Daily News:


(Source: Society for Neuroscience) - A cholesterol drug commonly prescribed to reduce cardiovascular disease risk restores blood vessel function in a mouse model of Alzheimer's disease, according to a new study.

The drug simvastatin (Zocor®) - which works by slowing cholesterol production - also improves learning and memory in adult, but not aged Alzheimer's model mice. The findings add to a growing body of evidence that early treatment with statins protects against some of the symptoms of Alzheimer's disease.

Go to full story: http://www.sfn.org


j fenwick
Posted: Thursday, April 5, 2012 12:05 PM
Joined: 3/20/2012
Posts: 15


I thought that the fda was putting out new warning labels on statins that they caused memory loss and confusion. we took our mother off of this medicine because of this new warning
Lane Simonian
Posted: Thursday, April 5, 2012 3:16 PM
Joined: 12/12/2011
Posts: 4845


The authors of the following articles are skeptical about the use of statins to prevent or treat Alzheimer's disease.  Statins may cause global amnesia by lowering levels of Coenzyme Q10 and by inhibiting the activation of phospholipase C beta.  The former action would increase the risk for Alzheimer's disease; the latter would decrease the risk for Alzheimer's disease.  

  

http://www.nhs.uk/news/2012/04april/Pages/papers-claim-statins-stop-alzheimers.aspx 

http://www.medicalnewstoday.com/releases/146041.php 

 

Statins have resulted in memory problems for some individuals, although the assertion so far is that these memory problems have been reversed once the affected individuals stopped taking the statins.  The producers of statin medications seem to want to hold onto the possibility that statins are a benefit in regards to either the prevention or treatment of Alzheimer's disease, but the number of people helped by statins would probably be few if any, and the memory problems (even if reversible) are real for certain statin users. 


Myriam
Posted: Thursday, April 5, 2012 7:47 PM
Joined: 12/6/2011
Posts: 3326


Interesting. Works in mice, though. :)) laughing
Lane Simonian
Posted: Thursday, April 5, 2012 8:01 PM
Joined: 12/12/2011
Posts: 4845


Here is a little more on statins and memory loss and other risk factors associated with statins. 

http://www.boston.com/Boston/dailydose/2012/03/statin-side-effects-how-common-are-memory-loss-diabetes-and-muscle-aches/jjSsnfRshNt7TWQHbSsxJP/index.html 

 

I know that it is a little strange that one month after the FDA issues a warning about statins and memory loss, a study touts statins as a possible means to prevent Alzheimer's disease.  Many drugs act on different systems and thus can produce different results for different people.  My complaint against statins and other drugs is that they are widely prescribed to people who probably don't need them and that some of these people end up suffering from problems caused by the medications.  Plus, people are scared into taking drugs that may have just the opposite effect for which they are being prescribed.  My sister's doctor, for example, told her she should take statins not only to lower her cholesterol levels but to protect against memory loss (this was before the FDA warning).  Others took Fosamax and other bisphosphonate drugs to protect their bones, and then ended up having atypical femur breaks or jaw necrosis.  The benefits of drugs are routinely overstated and their side effects are just as often understated.   


Lane Simonian
Posted: Thursday, April 5, 2012 9:20 PM
Joined: 12/12/2011
Posts: 4845


One of these days what worked in mice is also going to work in humans. It just hasn't happened, yet.