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Grape-derived Compound Prevents Alzheimer's Progression in Mice
Myriam
Posted: Friday, May 4, 2012 5:10 PM
Joined: 12/6/2011
Posts: 3326


From Alzheimer's Daily News:


Grape-derived Compound Prevents Alzheimer's Progression in Mice


(Source: Mount Sinai Hospital) - Mount Sinai School of Medicine researchers have succeeded in developing a biosynthetic polyphenol that improves cognitive function in mice with Alzheimer's disease (AD). The findings provide insight in determining the feasibility of biosynthetic polyphenols as a possible therapy for AD in humans.

 

Polyphenols, which occur naturally in grapes, fruits, and vegetables, have been shown to prevent the cognitive decline associated with AD in a mouse model, but the molecules are very complex and are extensively metabolized in the body.

 

Dr. Giulio Pasinetti and collaborators analyzed the structure of this polyphenol by nuclear magnetic resonance imaging and recreated it biosynthetically in the laboratory. The team discovered that the synthetic polyphenol generated in the laboratory also promoted plasticity and benefits in learning and memory functions in the brains of the mice.

 

This is the first study to determine which specific subfraction of these molecules penetrates the animal brain, and demonstrate that a drug compound similar to polyphenols can exert similar bioactivities.

 

"While this is an exciting development, we have a lot to discover and many years of testing before this agent can be considered in humans," said Pasinetti. "I look forward to further studying this compound to determine its feasibility as a treatment for Alzheimer's disease."

 

Go to full story: http://www.mountsinai.org


John1943
Posted: Monday, May 7, 2012 3:26 PM
Joined: 4/18/2012
Posts: 21


Here is a grape-derived compound that we discussed before (for humans) that is in the archives:

 

Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides.

http://www.ncbi.nlm.nih.gov/pubmed/16162502

 

John

 


Myriam
Posted: Monday, May 7, 2012 11:37 PM
Joined: 12/6/2011
Posts: 3326


Thanks, John!