RSS Feed Print
Link Between Brain Insulin Resistance, Neuronal Stress in Worsening Alzheimer's Disease
Myriam
Posted: Tuesday, June 26, 2012 8:06 PM
Joined: 12/6/2011
Posts: 3326


From Alzheimer's Daily News:


(Source: ScienceDaily) - Researcher Dr. Suzanne de la Monte reports a link between brain insulin resistance (diabetes) and two other key mediators of neuronal injury that help Alzheimer's disease (AD) to propagate. The research found that once AD is established, therapeutic efforts must also work to reduce toxin production in the brain.


"Brain insulin resistance (diabetes) is very much like regular diabetes," explained de la Monte. "Since the underlying problems continue to be just about the same, we believe that the development of new therapies would be applicable for all types of diabetes, including Alzheimer's disease, which we refer to as Type III diabetes."

 

She added: "This study points out that once AD is established, therapeutic efforts should target several different pathways - not just one. The reason is that a positive feedback loop gets going, making AD progress. We have to break the vicious cycle. Restoring insulin responsiveness and insulin depletion will help, but we need to reduce brain stress and repair the metabolic problems that cause the brain to produce toxins."

Growing evidence supports the concept that AD is fundamentally a metabolic syndrome that leads to abnormalities linked to brain insulin and insulin-like growth factor (IGF) resistance. In AD, brain insulin and IGF resistance and deficiencies begin early and worsen with severity of the disease. The rationale behind the progression of the disease is that insulin-resistance dysregulates lipid metabolism and promotes ceramide accumulation, thereby increasing inflammation and lipid metabolism, causing toxic ceramides to accumulate in the brain. The end result is increased stress that threatens the survival and function of neurons in the brain.

 

Go to full story:
http://www.sciencedaily.com/releases/2012/06/120626115249.htm