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Epilepsy Drug Reverses Memory Loss in Animal Alzheimer's Model
Myriam
Posted: Wednesday, August 8, 2012 12:15 AM
Joined: 12/6/2011
Posts: 3326


From Alzheimer's Daily News:


(Source: Gladstone Institutes) - Scientists at the Gladstone Institutes have discovered that an FDA-approved anti-epileptic drug reverses memory loss and alleviates other Alzheimer's-related impairments in an animal model of the disease.

Dr. Lennart Mucke and colleagues showed how levetiracetam - a drug commonly prescribed for patients who suffer from epilepsy - suppresses abnormal brain activity and restores memory function in laboratory mice.

The scientists found that administering levetiracetam to the mice reduced abnormal network activity in their brains by 50% in less than a day. After two weeks of treatment, the neurons' ability to communicate with each other improved. The mice also showed better learning and memory in a maze test. Finally, the researchers observed that several proteins that are important for healthy brain function returned to normal levels.



"Until larger human trials have been completed, we caution against any off-label use of levetiracetam," Dr. Mucke said. "But the consistency between our findings and those just obtained by our colleagues at Johns Hopkins is truly remarkable and, in my opinion, merits additional clinical trials."

 

Go to full story: http://www.eurekalert.org