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Scientists Reverse Alzheimer's-Like Memory Loss in Animal Models
Posted: Tuesday, September 25, 2012 10:14 PM
Joined: 12/6/2011
Posts: 3326

From Alzheimer's Daily News:

(Source: ScienceDaily) - A team of neuroscientists and chemists from the U.S. and China published research suggesting that a class of currently used anti-cancer drugs, as well as several previously untested synthetic compounds, show effectiveness in reversing memory loss in two animal models of Alzheimer's disease.

Yi Zhong who led the research conducted in fruit flies and mice, reported that he and his colleagues were surprised with their results, which, he stressed, used two independent experimental approaches "the results of which clearly converged."

Specifically, the research suggests a "preferred target" for treating memory loss associated with the amyloid-beta (Aß) plaques seen in advanced Alzheimer's patients. That target is the epidermal growth factor receptor, often called by its acronym, EGFR.


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Lane Simonian
Posted: Tuesday, September 25, 2012 11:20 PM
Joined: 12/12/2011
Posts: 4854

Epidermal growth factor receptors and platelet derived growth factor receptors are receptors that activate phospholipase C gamma--an enzyme which plays a critical role in the cascade that leads to Alzheimer's disease. 


Phenolic compounds in various fruits, vegetables, spices, and essential oils can inhibit these receptors and thus may help to delay the onset of Alzheimer's disease.  The most effective phenolic compounds later act as antioxidants (peroxynitrites scavengers) and can be used to treat the disease.