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Researchers Find Test for Dementia 'Flawed'
Posted: Tuesday, December 18, 2012 4:07 PM
Joined: 12/6/2011
Posts: 3326

(Source: - The search for a drug to treat Alzheimer's disease could be being undermined by flaws in a test used in clinical trials to assess patients. And though few experts would blame the test for the recent failures of potential new drugs, a major push is now on to produce more sensitive ways of measuring the progress of the disease.

During the past few years, a number of clinical trials have produced disappointing results for high-profile drugs, and some pharmaceutical companies have abandoned Alzheimer's disease altogether. Jeremy Hobart, a neurologist, says that flaws in the ADAS-Cog (Alzheimer's Disease Assessment Scale - Cognitive Behaviour section) test could be partly responsible.


In many trials branded 'failures', this has been used as the key test of whether a drug is working. There is, says Hobart, an argument that any study that has used ADAS-Cog may have underestimated changes in and differences between patients given the drug and controls. Hobart and his colleagues have detailed the flaws in the test that undermine its utility.


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