RSS Feed Print
A Ginkgo Biloba Extract Promotes Proliferation of Endogenous Neural Stem Cells
Myriam
Posted: Thursday, July 25, 2013 4:01 PM
Joined: 12/6/2011
Posts: 3326


Neural stem cells proliferate in the subventricular zone and hippocampal dentate gyrus of adult mammals. However, the number of endogenous neural stem cells is insufficient to prevent cerebral ischemia/reperfusion injuries such as vascular dementia, so it is important to stimulate endogenous neural stem cell proliferation and differentiation. The ginkgo biloba extract EGb761 effectively and safely treats memory loss and cognitive impairments in patients with senile dementia. 


 

Prof. Yuliang Wang and team from Weifang Medical University observed the effects of EGb761 on proliferation of neural stem cells in the subventricular zone and dentate gyrus of rats with vascular dementia. Researchers found that the ginkgo biloba extract EGb761 promoted and prolonged the proliferation of neural stem cells in the subventricular zone and dentate gyrus of rats with vascular dementia. The cells continued to proliferate at 4 months. EGb761 also significantly improved learning and memory in rats with vascular dementia. 

 

These findings which were published in the Neural Regeneration Research (Vol. 8, No. 18, 2013) provide a new idea and approach to further explore the induced proliferation of neural stem cells in situ in the treatment of vascular dementia. 


onward
Posted: Thursday, July 25, 2013 6:33 PM
Joined: 12/20/2011
Posts: 217


 

Thanks for posting, Myriam.  Very interesting. 

 

 

If I understand right, the clinical trials using ginkgo for memory have been mixed.  But on the positive side, ginkgo is the only supplement that WebMD rates as "possibly effective" for "memory impairment."

http://www.webmd.com/vitamins-supplements/condition-1746-Memory+impairment.aspx?diseaseid=1746&diseasename=Memory+impairment&source=2

 

WebMD also considers ginkgo to be one of the supplements "possibly effective" for Alzheimer's:

http://www.webmd.com/vitamins-supplements/condition-981-Alzheimer%27s+disease.aspx?diseaseid=981&diseasename=Alzheimer%27s+disease&source=2

And according to a press release, this EGb761 (the specific ginkgo used in the study you cited) is readily available over-the-counter in the U.S.:

"In the U.S., EGb761 is sold under the Ginkgold brand name and
distributed to natural product stores by Nature's Way Products, Inc..."


http://www.prnewswire.com/news-releases/us-study-proves-efficacy-of-patented-ginkgo-extract-for-alzheimersdementia-within-26-weeks-72596862.html 


Myriam
Posted: Thursday, July 25, 2013 11:12 PM
Joined: 12/6/2011
Posts: 3326


Thanks for these sites!