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Resveratrol study
Lane Simonian
Posted: Saturday, September 12, 2015 10:07 AM
Joined: 12/12/2011
Posts: 4863


A recent study on resveratrol indicated that it can help improve functions of daily living, but not overall cognition (at least not in this study).

http://www.livescience.com/52157-resveratrol-alzheimers-disease.html

At certain dosages, reservatrol can cross the blood-brain barrier. Resveratrol is a peroxynitrite scavenger but at certain levels it can also be a pro-oxidant.

http://www.resveratrolnews.com/will-resveratrol-alzheimers-study-doom-red-wine-molecule-once-and-for-all/608/



Eden Desjardins
Posted: Monday, September 14, 2015 10:28 AM
Joined: 5/25/2015
Posts: 48


Thank you for sharing this. It seems like this molecule is accompanied by an uncertainty of negative effects with overdosage(similar to almost all drugs) and researchers are still trying to find the appropriate dosage.

Excellent though, I'd be keeping an eye on updates in this field as I've heard of this molecule.

The_Sun_Still_Rises
Posted: Monday, September 14, 2015 5:24 PM
Joined: 7/24/2015
Posts: 3020


It is also used to treat Lyme disease, that can often get much, much worse when treated in people who may not know they have it (lab tests only have a 35% chance of catching it)...that could be very negative in someone with dementia or alz.
Lane Simonian
Posted: Monday, September 14, 2015 7:46 PM
Joined: 12/12/2011
Posts: 4863


Thank you for both comments. Resveratrol (and curcumin) activates an enzyme called AMPK that usually contributes to cell survival but can contribute to cell death under conditions of oxidative stress. Resveratrol helps to reduce this oxidative stress to the extent that perhaps its activation of AMPK is not a problem in the brain. On the other hand, not much resveratrol and curcumin make it to the brain.

Lyme disease is likely also the result of oxidative stress, so it makes sense that resveratrol might help in its treatment as well.

Oxidative stress can damage DNA, proteins, and lipids, this damage has been proposed to contribute to diseases and disorders such as cancer, Parkinson's, Alzheimer's, atherosclerosis, chronic fatigue syndrome, and possibly Lyme borreliosis .

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392059/

Once the best antioxidants or combination of antioxidants is discovered then good treatments for Alzheimer's disease are likely to become available.

scma_2007
Posted: Saturday, November 14, 2015 11:12 AM
Joined: 9/13/2013
Posts: 112


Regarding this  link - 

 http://www.livescience.com/52157-resveratrol-alzheimers-disease.html  (9/11/2015)

 I have been following the research mentioned in this resveratrol article. The highest dose of resveratrol tested was one gram by mouth twice daily.  Here's the link that discuss the dosage in more detail-

Oral Resveratrol Stabilizes Amyloid in Alzheimer's (11/2014)
http://www.medscape.com/viewarticle/835614

The clinical trial led by Dr Turner at Georgetown University published their conclusion in their website news. The trial has established the fact that resveratrol can stabilized the beta amyloid (plaque) by reducing inflammation.The news -

Resveratrol Impacts Alzheimer’s Disease Biomarker (9/11/2015)
https://gumc.georgetown.edu/news/resveratrol-impacts-alzheimers-disease-biomarker

This trial was the second phase.

It was interesting that in the first phase of this trial, they found there is a high percentage of undiagnosed pre-diabetes in the participants.

Undiagnosed pre-diabetes highly prevalent in early Alzheimer's disease study http://www.sciencedaily.com/releases/2013/07/130714160840.htm (7/14/2013)