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Salsalate
Blairrw
Posted: Sunday, December 20, 2015 3:51 PM
Joined: 3/7/2012
Posts: 1


There is some news that Salsalate, an old drug, has been effective in improving memory loss?

Has anyone heard about this and are there any trials or evidence?


Lane Simonian
Posted: Tuesday, December 22, 2015 1:08 PM
Joined: 12/12/2011
Posts: 4586


Welcome Blairrw.  Salsalate is an nntioxidant which inhibits the formation of the oxidant peroxynitrite which is probably the key oxidant in Alzheimer's disease.  It may work better as a preventative measure that as a treatment--similar but perhaps better than aspirin in this regard (acetylsalicylic acid).
Eden Desjardins
Posted: Monday, January 4, 2016 10:57 AM
Joined: 5/25/2015
Posts: 48


It seems promising but the research done seems to be quite recent and not reciprocated by other scientific sources beyond one - http://www.ncbi.nlm.nih.gov/pubmedhealth/behindtheheadlines/news/2015-09-22-could-an-arthritis-drug-also-help-treat-alzheimers-disease/

I would be wary about being lured into journalistic/sensationalistic tidbits like "Hippocrates mentioned this drug etc" because the Greeks knew very little about medicine back then, compared to what we know now and thus, requires further verification. Even still.. if Hippocrates observed improvements that's an interesting start. 

Still, seems quite promising, since mice brain models emulate the human brain quite well.