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Neuropsychiatric problems in dementia
Lane Simonian
Posted: Sunday, October 16, 2016 12:34 PM
Joined: 12/12/2011
Posts: 4863


Norepinephrine levels are higher in Alzheimer's patients with neuropsychiatric problems than those without.

The behavioral and psychological symptoms of dementia (BPSD) are common serious problems that are a major contributor to caregiver burden. Despite their significance, the underlying neurobiology of these disturbances is still unclear. This review examines the role of norepinephrine (NE) on BPSD, including depression, aggression, agitation and psychosis. A number of lines of evidence suggest that NE dysfunction leading to BPSD may result from increased NE activity and/or hypersensitive adrenoreceptors compensating for loss of NE neurons with progression of Alzheimer's disease (AD). With greater appreciation of the underlying neurobiology of behavioral and psychological symptoms of dementia (BPSD) more effective, rational, targeted pharmacotherapy will hopefully emerge.

Stress is one of the factors that lead to higher norepinephrine levels.  Ferulic acid helps to limit the release of norepinephrine by antagonizing beta-1 adrenergic receptors.


A highly selective beta1-adrenergic blocker with partial beta2-agonist activity derived from ferulic acid [ferulinolol], an active component of Ligusticum wallichii Franch.

 

Here are the results of studies using ferulic acid in heat processed ginseng and feru-guard to treat neuropsychiatric problems in dementia.


 2012 Nov;15(6):278-82. doi: 10.1179/1476830512Y.0000000027.

Heat-processed ginseng enhances the cognitive function in patients with moderately severe Alzheimer's disease.

RESULTS:

The treatment groups showed significant improvement on the MMSE and ADAS. Patients with higher dose group (4.5 g/day) showed improvements in ADAS cognitive, ADAS non-cognitive, and MMSE score as early as at 12 weeks, which sustained for 24-week follow-up.

DISCUSSION:

These results demonstrate the potential efficacy of a heat-processed form of ginseng on cognitive function and behavioral symptoms in patients with moderately severe AD.




Effects of ferulic acid and Angelica archangelica extract (Feruguard) in patients with Alzheimer's disease





Results: In the 12 patients of group A at completion of testing, mean NPI [Neuropyshiatric Inventory] score was observed to have decreased significantly (P = 0.003) from 18.08 before administration to 10.58 after administration. In addition, distress scores also decreased significantly (P = 0.000) from 12.17 to 7.50, thus demonstrating the ameliorative effects of Feru-Guard on BPSD. There were no significant differences observed for MMSE, ADAS or GDS15 scores before and after administration. In the comparison of changes in cerebral blood flow, significant increases were observed in the right occipital lobe, and left cerebellar hemisphere as compared with before administration.Conclusions: This study verified the usefulness of Feruguard for BPSD. We intend to conduct additional studies on larger numbers of subjects in the future.

 2011 Jul;11(3):309-14. doi: 10.1111/j.1447-0594.2010.00687.x. Epub 2011 Jan 28.

Effect of ferulic acid and Angelica archangelica extract on behavioral and psychological symptoms of dementia in frontotemporal lobar degeneration and dementia with Lewy bodies.

 

RESULTS:

Treatment with Feru-guard led to decreased scores on the Neuropsychiatric Inventory in 19 of 20 patients and significantly decreased the score overall. The treatment also led to significantly reduced subscale scores on the Neuropsychiatric Inventory ("delusions", "hallucinations", "agitation/aggression", "anxiety", "apathy/indifference", "irritability/lability" and "aberrant behavior"). There were no adverse effects or significant changes in physical findings or laboratory data.

CONCLUSION:

Feru-guard may be effective and valuable for treating the behavioral and psychological symptoms of dementia in frontotemporal lobar degeneration and dementia with Lewy bodies.


alzcare1247
Posted: Thursday, January 12, 2017 8:58 PM
Joined: 1/12/2017
Posts: 21


Where can you get Feru-guard to purchase?
Lane Simonian
Posted: Friday, January 13, 2017 12:35 AM
Joined: 12/12/2011
Posts: 4863


Unfortunately, Feru-guard may be difficult to purchase.  The Japanese company that produces it is called Glovia.  It looks like it can only be attained through a medical institution.  I did find an email address for overseas inquiries on a blog on Feru-guard: dementia_japan@yahoo.co.jp.  If you try, let me know if the email works and if you get any response. 
Lane Simonian
Posted: Friday, January 13, 2017 10:43 AM
Joined: 12/12/2011
Posts: 4863


I found an email for one of the doctors doing research on Feru-guard: oguro@med.shimane-u.ac.jp.  

http://www.scientiapublications.com/wp-content/uploads/2016/10/Hiroaki-Oguro.pdf



Lane Simonian
Posted: Saturday, January 14, 2017 11:12 AM
Joined: 12/12/2011
Posts: 4863


Here is the clinical research contact information for Glovia.

Public contact Name of contact person Shinya Yamamoto Organization Glovia Co., Ltd. Division name Department of clinical research Address 2-9-6-7F Shinkawa Chuo-ku Tokyo TEL 03-6228-3376 Homepage URL Email yamamoto@glovia.co.jp