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Lipogen PS Plus
Posted: Monday, September 17, 2018 12:05 AM
Joined: 1/20/2018
Posts: 10

Hi: Has anyone heard anything about the effectiveness of Lipogen PS Plus to improve cognitive function and memory?


Lane Simonian
Posted: Monday, September 17, 2018 10:15 AM
Joined: 12/12/2011
Posts: 4632

At certain levels, phosphatidylserine appears to suppress immune cells (mircoglia) activation and thus limits the production of peroxynitrite which may help in the treatment of Alzheimer's disease, at least early on.  Peroxynitrite limits the production of acetylcholine which is needed for the retrieval of short-term memory.

Our data demonstrated that PS/PC liposomes have an inhibitory effect on the Abeta/IFN-gamma-induced microglial production of inflammatory molecules such as TNF-alpha, NO, and O2 − , and they thus presumably prevent the subsequent formation of ONOO− . Accordingly, PS/PC liposomes appear to have both neuroprotective and antioxidative properties through the inhibition of microglial activation and to be a potentially useful treatment for microglial activation-mediated neurodegenerative diseases including AD.

Phosphatidyserine studies are quite mixed (perhaps the dose makes the difference and maybe the source, too), but here are the most positive ones.

The present results showed that AD patients taking 300 mg PS/day for 20 continuous weeks significantly improved vocabulary and picture scores, which is consistent with clinical trial results showing that taking PS can improve memory in many healthy or memory impaired subjects. Dr. Crook from the Memory Assessment Clinics performed a cooperation development trial with 149 healthy subjects. The results showed that, compared with the placebo group, the daily use of PS for 12 weeks significantly improved the ability to remember names and faces, recalling names and faces, and recognizing faces. Among these patients, 57 with severe memory barriers (average age 64.3 years) took PS orally, remembering their phone number, recalling misplaced objects, attention during reading, talking, and working improved significantly. Zanotta et al. (2014) performed a double-blind test on 170 volunteers whose average age was 65.7 years old and who took 300 mg PS/day for 3 continuous months. The results showed that, compared with the placebo group, attention and vigilance test results significantly improved. A long-term study showed that 425 subjects over 65 years of age with moderate to severe cognitive function degradation took 200 mg/day of PS for continuous 6 months and processing information, recalling digital images, and emotion significantly improved. Finally, a diet containing PS for 60 continuous days significantly improved the cognitive scores of AD patients (Sato et al., 2010; Grimm et al., 2013; Zanotta et al., 2014).


Hopefully, someone here has direct experience with the supplement.