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Left Prefrontal Repetitive Transcranial Magnetic Stimulation in a Logopenic Variant of Primary Progressive Aphasia: A Case Report. Bereau M1, Magnin E, Nicolier M, Berthet L, Dariel E, Ferreira S, Syl
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Posted: Saturday, November 16, 2019 6:48 PM
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Left Prefrontal Repetitive Transcranial Magnetic Stimulation in a Logopenic Variant of Primary Progressive Aphasia: A Case Report.

Author information

1 Department of Memory Center of Research and Resources (CMRR), University Hospital of Besanx00E7;on, Besanx00E7;on, France.

Abstract

BACKGROUND/AIMS:

High frequency repetitive transcranial magnetic stimulation (hf-rTMS) improves language skills in Alzheimer's disease (AD). We report the use of hf-rTMS in a patient with logopenic primary progressive aphasia (LPPA) due to AD.

METHOD:

hf-rTMS was applied to the left dorsolateral prefrontal cortex of a LPPA patient. Cerebral perfusion, neuropsychological and linguistic performances were evaluated before and 1 month after hf-rTMS.

RESULTS:

The tolerance was good. Improvements on linguistic (fluency, naming, lesser paraphasia) and cognitive skills (Mini Mental State Examination, verbal memory free recall, speed processing) and cerebral perfusion were observed.

CONCLUSION:

hf-rTMS can be used in LPPA patients. A procognitive effect persisting several weeks after stimulation in LPPA patients was suggested and should therefore be evaluated in a clinical trial as an adjunctive therapeutic tool.

PMID:  27344155  DOI:  10.1159/000447399
[Indexed for MEDLINE]