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This is nearly it: aromatic compounds in the treatment of Alzheimer's disease
Lane Simonian
Posted: Wednesday, May 13, 2020 12:35 PM
Joined: 12/12/2011
Posts: 4854


Aromatic compounds such as those found in various essential oils, ginseng, and marijuana likely hold the key to the treatment of Alzheimer's disease (although non-aromatic compounds may play a role as well).  Here is a very good article making some critical links:

Designing Alzheimer's Therapies at the Molecular Level

Overview of a rational strategy for designing compact aromatic molecules with multiple reactivities against pathological factors found in the Alzheimer's disease-affected brain and the chemical series studied in this work.

Sometimes the most complex problems actually have very simple solutions. A group of South Korean researchers reported an efficient and effective redox-based strategy for incorporating multiple functions into simple molecular reagents against neurodegenerative disorders. The team developed redox-active aromatic molecular reagents with a simple structural composition that can simultaneously target and modulate various pathogenic factors in complex neurodegenerative disorders such as Alzheimer’s disease.

A number of pathogenic elements such as reactive oxygen species, amyloid-beta, and metal ions have been suggested as potential causes of Alzheimer’s disease. Each element itself can lead to Alzheimer’s disease, but interactions between them may also aggravate the patient’s condition or interfere with the appropriate clinical care.

For example, when interacting with amyloid-beta, metal ions foster the aggregation and accumulation of amyloid-beta peptides that can induce oxidative stress and toxicity in the brain and lead to neurodegeneration.

Because these pathogenic factors of Alzheimer’s disease are intertwined, developing therapeutic agents that are capable of simultaneously regulating metal ion dyshomeostasis, amyloid-beta agglutination, and oxidative stress responses remains a key to halting the progression of the disease.

Professor Lim said, “This strategy is straightforward, time-saving, and cost-effective, and its effect is significant. We are excited to help enable the advancement of new therapeutic agents for neurodegenerative disorders, which can improve the lives of so many patients.”