RSS Feed Print
Oxidation, nitration, hydrogen donation, Alzheimer's disease
Lane Simonian
Posted: Monday, August 31, 2020 10:09 PM
Joined: 12/12/2011
Posts: 4845


Oxidation (the loss of hydrogen atoms) and nitration (the addition of NO2) are likely the root causes of Alzheimer's disease.  Oxidation and nitration damage critical receptors, enzymes, and transport systems in the brain.  A couple of examples.  The oxidation of g protein-coupled receptors contributes to a loss of smell, distrurbed sleep, loss of social recognition, and the inability to retrieve short-term memories.  The nitration of the phosphatidyinositol-3 kinase enzyme, prevents the regeneration of neurons, synapses, and axons in the brain and inhibit neurotransmissions.  Oxidation and nitration also affects the activities of enzymes involved in the death of neurons.

The key to treating Alzheimer's disease is to find compounds that readily donate hydrogen atoms.  These compounds add hydrogen back to receptors, enzymes, and transport system, scavenge peroxynitrite, and in the process of scavenging peroxynitrite produce water which helps to de-nitrate proteins.  Among the substances that partially reverse oxidation, scavenge peroxynitrite, and de-nitrate proteins are panax ginseng, medicinal marijuana, essential oils via aromatherapy, and Anavex 2-73.  There is an urgent need to determine which substances are the best hydrogen donors and to test these substances for the treatment of Alzheimer's disease.  They can likely greatly slow down, stabilize, and in some aspects improve the conditions of people with Alzheimer's disease.


wolfewoman
Posted: Tuesday, September 1, 2020 10:21 PM
Joined: 1/1/2018
Posts: 206


Maybe crazy question but what about hydrogenated water? I bought tablets to drop nto my water.
Lane Simonian
Posted: Tuesday, September 1, 2020 10:46 PM
Joined: 12/12/2011
Posts: 4845


Not a crazy question at all.  Various forms of hydrogen have been suggested for the treatment of Alzheimer's disease including hydrogen-rich water.

The role of hydrogen in Alzheimer’s disease

Mechanisms of the Hydrogen Therapy in Alzheimer’s Disease


Inflammation and oxidative stress are recognized as the main causes of AD...hydrogen molecules such as hydrogen-rich water, hydrogen-rich saline or hydrogen inhalation exhibit anti-inflammatory and anti-oxidant effects in many studies.

And this one:

Lane Simonian
Posted: Tuesday, September 1, 2020 11:13 PM
Joined: 12/12/2011
Posts: 4845


A bit further afield and in mice, but still a useful study:

Protective effect of molecular hydrogen against oxidative stress caused by peroxynitrite derived from nitric oxide in rat retina

Results: H2 [molecular hydrogen in hydrogen-rich water, for instance] suppressed loss of mitochondrial membrane potential and apoptosis in retinal cells. Moreover, H2 decreased the tyrosine nitration level and suppressed oxidative stress damage in retinal cells...These findings suggest that H2 has a neuroprotective effect against retinal cell oxidative damage, presumably by scavenging peroxynitrite.

Conclusions: H2 reduces cellular peroxynitrite, a highly toxic reactive nitrogen species. Thus, H2 may be an effective and novel clinical tool for treating glaucoma and other oxidative stress-related diseases [i.e. Alzheimer's disease].