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in Mice, Antarctic krill oil-based diet elicits neuroprotective effects (MS)
HowDoYouDeal
Posted: Friday, January 8, 2021 12:56 PM
Joined: 2/17/2019
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Antarctic krill oil-based diet elicits neuroprotective effects

https://www.sciencedirect.com/science/article/pii/S1756464620305338?dgcid=rss_sd_all
Journal of Functional Foods

An antarctic krill oil-based diet elicits neuroprotective effects by inhibiting oxidative stress and rebalancing the M1/M2 microglia phenotype in a cuprizone model for demyelination


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It has been reported that KO can regulate lipid metabolism, and exert anti-inflammatory and anti-oxidative properties due to its eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) content (Ierna, Kerr, Scales, Berge, & Griinari, 2010). In addition, KO is rich in the carotenoid astaxanthin (AST), which mediates its antioxidant defense activity (Ambati, Phang, Ravi, & Aswathanarayana, 2014). With these respective findings, the investigators consider that KO is a potential therapeutic agent which can effectively alleviate the symptoms of MS. Therefore, the present study was designed to investigate the neuroprotective effect of KO on oxidative stress and microglia polarization in CPZ mice, and the potential of KO to initiate remyelination, as well as the possible role of the HDAC3/p-STAT3/NF-κB signalling pathway in these processes.