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Does Synchronizing Brain Waves Bring Harmony
HowDoYouDeal
Posted: Saturday, April 17, 2021 4:03 PM
Joined: 2/17/2019
Posts: 380


  • Light and sound therapy boost gamma waves, neuronal connections in mild AD.
  • Eight weeks of daily stimulation quieted cytokines, neuroinflammation.
  • Six-month trial missed primary, but met some secondary endpoints.

Entrainment Entertainment? Volunteers watched hundreds of flashing LED lights mounted on a four-square foot panel, and heard a high-definition sound bar buzz, both at 40 Hz. A center tablet entertained them to help them sit through an hour of this. [Courtesy of Li-Huei Tsai, MIT.]


HowDoYouDeal
Posted: Saturday, April 17, 2021 4:16 PM
Joined: 2/17/2019
Posts: 380


Participants watched and listened for one hour daily over six or nine months, at home.

 To monitor compliance, the researchers recorded participants as they watched, logging how long the device was on and tracking their eye movements.

 Participants wore a clinical-grade Fitbit every day to track their activity and sleep. Researchers tested participants’ memory at baseline, one month, and three months, and captured structural and functional MRIs at baseline and three months.

 Three months into this trial, pandemic lockdowns halted data collection and delayed its follow-up timeline.

 

Here is what the scientists were able to glean thus far:

  Within one month, participants treated with flickers and hums slept better, and woke up less often during the night, than those treated with control settings

 . Functional MRI suggested three months of active treatment had strengthened connections in areas that process sight and in the posterior cingulate, a part of the default mode network involved in memory.

 Structural MRI suggested active treatment may have preserved tissue in the hippocampus, whereas control treatment did not slow atrophy.

  The eight people who received three months of flickers and buzz remembered more face-name pairs than the seven controls, and the difference correlated with stronger brain connectivity.


HowDoYouDeal
Posted: Saturday, April 17, 2021 4:16 PM
Joined: 2/17/2019
Posts: 380


In 2016, Tsai and her MIT colleague Ed Boyden co-founded Cognito Therapeutics in Cambridge, Massachusetts, to develop GENUS clinically. Rather than using the easel with the light panel and sound bar mounted to it, the company designed a wearable system dubbed GammaSense Stimulation (see image below). In 2018, it started three clinical trials in mild AD: Flicker, Overture, and Etude. The latter is expected to wrap up this year; the former two were presented at AD/PD.

AD Gearhead? The early version of Cognito’s apparatus combined black LED glasses with over-ear headphones. The next trials will use a sleek upgrade with a remote. [Courtesy of Annabelle Singer, Georgia Tech (left) and Kimberly Ha, KKH Advisors for Cognito Therapeutics (right).]