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Drug Target Improves Memory in Mouse Model of Alzheimer's
Posted: Friday, March 9, 2012 2:31 PM
Joined: 12/6/2011
Posts: 3326

From Alzheimer's Daily News:

(Source: Newswise) - Researchers at several universities have validated the protease cathepsin B (CatB) as a target for improving memory deficits and reducing the pathology of Alzheimer's disease (AD) in an animal model representative of most AD patients.

Abnormal accumulation of brain amyloid-ß peptides (Aß) is thought to cause the memory loss and amyloid plaque pathology of AD. Aß peptides are "cut" out from a larger protein called the amyloid precursor protein (APP) by an enzymatic "scissor" called ß-secretase, and aggregate to form plaques in the brain regions responsible for memory. Inhibiting the ß-secretase "scissors" from "cutting" the APP with a drug would reduce brain Aß levels and thereby improve memory deficits and reduce amyloid plaque pathology. The vast majority of AD patients have wild-type (WT) ß-secretase activity and thus the WT ß-secretase has been a target of great interest for a long time.

Investigator Vivian Hook, PhD, says the study could lead to new therapeutics to improve the memory deficits of AD.

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