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Amyloid Beta Peptide Levels Linked to Alzheimer's Disease
Myriam
Posted: Tuesday, March 20, 2012 7:09 PM
Joined: 12/6/2011
Posts: 3326


From Alzheimer's Daily News:


(Source: Eurekalert) - The effects of the bacterial endotoxin lipopolysaccharide (LPS) has been found to elevate amyloid beta (Aß) peptide levels in the brain, leading to short-term deficits in learning.

"We have found that after several injections with LPS toxin, (seven consecutive days of LPS administration) mice showed significant elevation in Aß levels in their brains," said Michael Chumley, assistant professor at Texas Christian University. "This elevation corresponds with a decreased ability to learn simple tasks."

Scientists have long thought that inflammation might stimulate the onset of Alzheimer's or other cognitive diseases. It is well known that one of the things that cause inflammation in the brain is Aß plaques, which are produced in response to inflammation. This leads to a self-perpetuating inflammation, where the product of inflammation leads to more inflammation.

"What is unique in our study is that we initiated the inflammation in the body of the animal and not in the brain, and it lead to both an elevation of Aß in the brain and learning deficits," said Chumley.

Go to full story: http://www.eurekalert.org