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New Twist Needed on Beta-Amyloid Marker for Dementia
Posted: Wednesday, March 28, 2012 3:57 PM
Joined: 12/6/2011
Posts: 3326

From Alzheimer's Daily News:

(Source: Medscape) - Results from a meta-analysis of 10,000 patients confirm that reliable blood-based biomarkers predicting cognitive decline remain elusive.

The systematic review focused on plasma levels of a number of amyloid-based markers, and found that overall, beta-amyloid 42:40 ratios predict dementia and Alzheimer's disease. However, significant heterogeneity in the study underlines the need for substantial investigation of plasma beta-amyloid.

Investigators remain hopeful that preclinical prediction of Alzheimer's disease could still be on the horizon.

"If large-scale screening is developed for dementia, a blood test of amyloid-beta levels can be a very practical, affordable, and noninvasive solution," said Alain Koyama, SM, from the University of California (SF). "Other methods exist which can predict dementia risk, but they often involve procedures such as magnetic resonance imaging or spinal taps, which can be less accessible, more expensive, and more invasive than a simple blood test."

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