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Fisetin
Swarfmaker
Posted: Tuesday, May 29, 2012 10:33 AM
Joined: 3/28/2012
Posts: 13


I recently learned about this  flavonoid found in strawberries (and other fruits and vegetables).  Its usefulness in combating AD was discovered in 2006 or 2007.  Interest seems to be growing in its uses for other diseases such as diabetes, Huntington's disease, and enhancing chemotherapy drugs.  See this article:

 

http://alzheimersweekly.com/content/strawberries-outperform-apple-day 

 

and 

 

http://en.wikipedia.org/wiki/Fisetin  

 

Some think it may be a good partner to curcumin. 

 

While I can't imagine a better tasting "medicine" than strawberries, eating 37 or more per day would be taxing on the alimentary system.  It is now available as a supplement.  Don't know the dosage.  Looks like 100mg per day.  If anyone knows more, please contribute! 


Lane Simonian
Posted: Tuesday, May 29, 2012 11:20 AM
Joined: 12/12/2011
Posts: 4779


Fisetin is another phenolic compound that has the potential to help treat Alzheimer's disease (and other diseases where peroxynitrites play a role including a varitey of other neurodegenerative disease, diabetes, and cancer) because it inhibits the formation of amyloid plaques, the production of peroxynitrites, and partially reverses the damage done by peroxynitrites.  Most polyphenolic compounds reach the brain in relatively limited amounts, so the question is what amount of these compounds and in what combinations does the most good.  Thanks for the information Swarfmaker.  Here's a good summary of Fisetin from Natural News. 

 

NaturalNews) Fisetin is a unique flavonoid compound found naturally in many fruits and vegetables including strawberries, blueberries and the skin of cucumbers. A wealth of scientific research now explains how a diet packed with raw fruits and vegetables can help prevent amyloid plaque formation in the aging brain and can promote the early destruction of cancer cells by triggering the body's innate immune response. Researchers reporting in the journal Neuroscience Letters found that fisetin is neuro-protective and helps to maintain normal memory processes while inhibiting plaque formation around synapses. The International Journal of Oncology has published the work of Chinese scientists documenting how fisetin promotes the natural death of potentially malignant breast cancer cells. Fisetin is rapidly emerging as a powerful tool in the arsenal against a number of diseases associated with premature aging.

Fruits and vegetables in their natural state are typically packed with polyphenols; these polyphenols are structurally bioactive and target specific areas of the body or help to lower oxidative stress and inflammation that is behind many disease processes. The brain is particularly sensitive to stress from a high rate of metabolism necessary to oxygenate and fuel the sensitive neurons that control memory and cognition.


Learn more: http://www.naturalnews.com/034545_fisetin_fruits_cancer.html#ixzz1wH9Bvtvd 

 

 

Boost Memory and Cognition

Researchers have found that fisetin operates in a very specific pathway to boost nerve cell glutathione levels and to reduce one of the most damaging free radicals, peroxynitrite. Scientists have determined that the natural compound protects nerve cells from damage during stroke, while at the same time maintaining vital energy production in the brain. Fisetin also prevents excess activation of specialized glial cells in the brain that helps deter inflammatory nerve damage, excitotoxicity, and declining neurological health. And fisetin reduces amyloid beta fiber accumulation to improve memory and thwart cognitive decline.

In a separate body of research, scientists examined the effect of fisetin from dietary and supplemental sources on breast cancer programmed cell death. Cancer cells normally are detected and destroyed by an alert immune system response. Inflammatory messengers such as TNFa (tumor necrosis factor alpha) allow cancer cells to become cloaked and invisible to our immune system, which prevents cancer cell death through the process known as apoptosis. Fisetin negates the damaging effect of TNFa, reducing systemic inflammation and enabling the normal immune response.

Many health-conscious individuals may not be immediately familiar with fisetin, although they already consume therapeutic quantities from their healthy dietary choices.
Nutrition experts recommend including fruits such as strawberries and mangoes as a source of dietary fisetin or supplementing with 50 mg per day to boost memory and high-level brain function and to promote natural cancer cell death.

Sources for this article include:
http://www.wellnessresources.com/health/articles/fisetin_demonstrates...
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775892/?tool=pubmed
http://www.ncbi.nlm.nih.gov/pubmed/18761054
http://www.ncbi.nlm.nih.gov/pubmed/21922137

Learn more: http://www.naturalnews.com/034545_fisetin_fruits_cancer.html#ixzz1wHAdZArL