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Immunology of Traumatic Brain Injury: a Prime Target for Alzheimer's Disease Prevention
Posted: Wednesday, August 1, 2012 2:46 PM
Joined: 12/6/2011
Posts: 3326

From Alzheimer's Daily News:

(Source: 7th Space) - Traumatic brain injury (TBI) is especially prevalent in young adults in the military and those involved in full-contact sports. Its pathological hallmark is one or more primary injury foci, followed by a spread to normal brain areas via cascades of inflammatory cytokines and chemokines. The result is amplification of the original tissue injury by microglia, which in many cases can pre-dispose the development of Alzheimer's disease (AD).

The inflammatory based progression of brain injury has been shown to be active in humans for up to 17 years post TBI. Unfortunately, all neuroprotective drug trials have failed, and specific treatments remain less than efficacious.


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