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Damaged Blood Vessels in The Brain
Posted: Thursday, August 2, 2012 5:52 PM
Joined: 12/6/2011
Posts: 3326

From Alzheimer's Daily News:

(Source: MDC) - Researchers in Germany suggest that autoimmune mechanisms play a significant role in the pathogenesis and progression of Alzheimer's and vascular dementia.

Antibodies are the defense molecules of the body's immune system against foreign invaders. If the antibodies cease to distinguish between "foreign" and "self", they attack the cells of the own body, and are thus referred to as auto-antibodies.


These can trigger autoimmune diseases. Marion Bimmler and colleagues found that the auto-antibodies bind to specific proteins of vascular cells and consequently damage the blood vessels of the brain. The reason: The auto-antibodies generate a continual stimulation of the receptor and at the same time trigger an increase in intracellular calcium ion levels. As a result, the blood vessel walls thicken, and blood flow to the brain is disturbed.


Further clinical trials are being planned.


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