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MDA7 compound as a treatment? Any insights? Interesting article
chamel
Posted: Wednesday, September 5, 2012 7:59 AM
Joined: 8/30/2012
Posts: 4


New compound offers cure for Alzheimer's    Asian News International
Mon, 3 Sep 2012
English
370 words
Copyright 2012. ANI
   

London, Sept. 3 -- Scientists at Cleveland Clinic in Ohio claim discovery of a new compound, which they believe could one day cure Alzheimer's disease.

They hope the compound could help Alzheimer's sufferers regain their memory and other vital brain functions under a new treatment.


"It was shown to be effective in preventing the progression of Alzheimer's. It restored functions in the model that we tested. A lot more research needs to be done, but there is major potential," the Daily Express quoted lead scientist Professor Mohamed Naguib as saying.

The Cleveland Clinic scientists came across the powerful compound while undertaking tests on a drug to control neurological pain for chemotherapy patients.

They discovered that the chemical mixture had anti-inflammatory properties, which they believed could be effective in treating a range of other conditions, most notably Alzheimer's disease.

Tests proved to be very positive - and hopes are now high that further research could lead to a mass-market drug.

In results published online in the Neurobiology Of Aging, the compound MDA7 was found to interact with receptors in the brain that play a role in the neuro-degenerative processes in Alzheimer's.

As a result, the development of the disease could be limited. Treatment with the compound restored cognition, memory and synaptic plasticity - a vital neurological building block on which learning and memory are based.

"Cleveland Clinic dedicated two years of research into the examination of this compound and our findings show it could represent a novel therapeutic target in the treatment of Alzheimer's disease," said Prof Naguib, head of Anaesthesiology at Cleveland Clinic Lerner College of Medicine.

"Development of this compound as a potential drug for Alzheimer's would take many more years, but this is a promising finding worthy of further investigation," he added.

Alzheimer's is an irreversible, fatal brain disease that slowly destroys memory and thinking skills.

There is currently no cure for the condition, which accounts for two-thirds of dementia cases.Published by HT Syndication with permission from Asian News International.


Myriam
Posted: Wednesday, September 5, 2012 12:27 PM
Joined: 12/6/2011
Posts: 3326


chamel wrote:

"Development of this compound as a potential drug for Alzheimer's would take many more years, but this is a promising finding worthy of further investigation," he added.


Sounds like at this time it's only available through trials, if that, but keep a look out. I'm sure we'll hear/read more about it. I found this:


Potential Drug for Treatement of Alzheimer's Disease Investigated

ScienceDaily (Aug. 31, 2012) — A compound developed to treat neuropathic pain has shown potential as an innovative treatment for Alzheimer's disease, according to a study by researchers at Cleveland Clinic's Lerner Research Institute and Anesthesiology Institute.


"Cleveland Clinic dedicated two years of research into the examination of this compound and our findings show it could represent a novel therapeutic target in the treatment of Alzheimer's disease," said Mohamed Naguib, M.D., Professor of Anesthesiology, Cleveland Clinic Lerner College of Medicine. "Development of this compound as a potential drug for Alzheimer's would take many more years, but this is a promising finding worthy of further investigation."

In a study published online in theNeurobiology of Aging, the compound MDA7 induced beneficial immune responses that limited the development of Alzheimer's disease. Treatment with the compound restored cognition, memory and synaptic plasticity -- a key neurological foundation of learning and memory -- in an animal model.

Neuroinflammation is an important mechanism involved in the progression of Alzheimer's disease. The MDA7 compound has anti-inflammatory properties that act on the CB2 receptor -- one of the two cannabinoid receptors in the body -- but without the negative side effects normally seen with cannabinoid compounds.

Alzheimer's disease is an irreversible, fatal brain disease that slowly destroys memory and thinking skills. About 5 million people in the United States have Alzheimer's disease. With the aging of the population, and without successful treatment, there will be 16 million Americans and 106 million people worldwide with Alzheimer's by 2050, according to the 2011 Alzheimer's Disease Facts and Figures report from the Alzheimer's Association.