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Newly Found Enzyme Works Two Ways to Fight Alzheimer's
Posted: Tuesday, September 18, 2012 12:56 PM
Joined: 12/6/2011
Posts: 3326

From Alzheimer's Daily News:

(Source: Fox News) - Alzheimer's disease affects over 5.5 million Americans and is the most common memory disorder worldwide. But despite all the attention it receives, no effective treatment has been found - until now.

Researchers led by Dr. Malcolm Leissring, a neuroscientist at Mayo Clinic in Florida, recently discovered an enzyme, BACE 2, that cuts beta-amyloid, effectively destroying the toxic protein prevalent in patients with Alzheimer's.

Previously discovered, BACE 1, cut the protein APP into fragments, which became beta-amyloid. BACE 2 cuts the beta amyloid fragments again, destroying the harmful protein. A second mechanism, then cuts these fragments, preventing them from further production of the protein.

The fact that BACE 2 can lower beta-amyloid by two distinct mechanisms makes this enzyme an especially attractive candidate for gene therapy to treat Alzheimer's disease," reported first author Dr. Samer Abdul-Hay.


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