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Interesting research
jfkoc
Posted: Wednesday, October 3, 2012 8:48 AM
Joined: 12/4/2011
Posts: 19280


not a trial but stumbled on to work being done by Peter Davies....new to me but maybe not to the rest of the world.
Lane Simonian
Posted: Wednesday, October 3, 2012 9:57 AM
Joined: 12/12/2011
Posts: 4854


More on his research. 

 

http://www.feinsteininstitute.org/Feinstein/Laboratory+of+Alzheimer+Disease+Research+

 

And a possible explanation. 

 

In cancer, peroxynitrites cause DNA damage and disables enzymes that would attack the cancer. 

 

http://www.jbc.org/content/279/9/7708.abstract 

http://ebm.rsmjournals.com/content/222/3/246.full (see section on peroxynitrites if interested). 

 

In Alzheimer's disease, the pathway that leads to cell growth is less activated than in cancer (or in some cases not at all such as people with presenilin gene mutations).  Then as they increase with amyloid plaques aggregation, peroxynitrites cut off this pathway altogether.  Peroxynitrites also deplete the enzymes that would prevent the death of neurons.  So somewhat paradoxically peroxynitrites contribute to cell growth in the case of cancer (through DNA damage), but cause cell death in the case of Alzheimer's disease (by allowing for the influx of calcium into cells).  This is why few people who have cancer rarely get Alzheimer's disease and vice versa, but the same culprit--peroxynitrites--plays a major role in both.   

 

One scientist who has close ties with people working on Alzheimer's research passed along this KEGG pathway for Alzheimer's disease.  It's not perfect and is indeed highly complicated, but at the bottom of the page is a summary of the damge done by peroxynitrites in Alzheimer's disease.  I believe all the arrows pointing to cell death (apoptosis) should go through peroxynitrites.  That's why if you neutralize peroxynitrites (with certain essential oils and sun ginseng, for example) and repair part of the damage you can at least partially reverse Alzheimer's disease. 

 

http://www.genome.jp/kegg/pathway/hsa/hsa05010.html