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Researchers Find Test for Dementia 'Flawed'
Myriam
Posted: Tuesday, December 18, 2012 4:07 PM
Joined: 12/6/2011
Posts: 3326


(Source: nature.com) - The search for a drug to treat Alzheimer's disease could be being undermined by flaws in a test used in clinical trials to assess patients. And though few experts would blame the test for the recent failures of potential new drugs, a major push is now on to produce more sensitive ways of measuring the progress of the disease.


During the past few years, a number of clinical trials have produced disappointing results for high-profile drugs, and some pharmaceutical companies have abandoned Alzheimer's disease altogether. Jeremy Hobart, a neurologist, says that flaws in the ADAS-Cog (Alzheimer's Disease Assessment Scale - Cognitive Behaviour section) test could be partly responsible.

 

In many trials branded 'failures', this has been used as the key test of whether a drug is working. There is, says Hobart, an argument that any study that has used ADAS-Cog may have underestimated changes in and differences between patients given the drug and controls. Hobart and his colleagues have detailed the flaws in the test that undermine its utility.

 

Go to full story:
http://www.nature.com/