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Serotinin and Memory
Posted: Wednesday, December 26, 2012 9:12 AM
Joined: 4/15/2012
Posts: 247

Anyone have any data on serotonin uptake and memory loss? I was on Lexapro for about a year, along with Wellbutrin, Namenda and Serequel. I weaned off the Lexapro about a week and half ago. Since that time my memory has been worse than it ever has been. During this time I was also ill and not able to take my daily coconut oil.
However I believe my memory loss has more to do with the Lexparo and the lack of serotonin uptake but cannot find any research to back this up? Has anyone had a similar reaction? Or cited any research to back up my theory

Mimi S.
Posted: Wednesday, December 26, 2012 10:11 AM
Joined: 11/29/2011
Posts: 7029


I do hope you are consulting with your doctor and are not stopping meds on your own.

Lane Simonian
Posted: Wednesday, December 26, 2012 12:35 PM
Joined: 12/12/2011
Posts: 4854

There are a number of studies suggesting a link between low levels of serotonin and memory problems. 


The exact mechanisms connecting low levels of serotonin to memory loss apparently are not known. 


On a more general levels, Alzheimer's disease damages a whole class of receptors (g protein-coupled receptors).  These include receptors involved in mood (serotonin and opioid), memory (muscarinic acetylcholine), sleep (melatonin), social recognition (oxytocin), alertness (dopamine), smell (olfactory), and brain growth (adrenergic). 

Posted: Thursday, December 27, 2012 10:24 AM
Joined: 12/20/2011
Posts: 217



Relating to what Lane posted... Here are a couple of interesting studies about a dietary supplement (whey)  that may increase serotonin and improve memory: 




Diet rich in alpha-lactalbumin improves memory in unmedicated recovered depressed patients and matched controls.



2006 Jul;20(4):526-35. Epub 2005 Sep 20.





"... Alpha-lactalbumin protein had no effect on mood, but improved abstract visual memory and impaired simple motor performance. These effects were independent of history of depression. Supplements of lactalbumin may be useful for nutrition research in relation to age- or disease-related memory decline. The present findings should be further examined in different (e.g. medicated) samples. The long-term effects of alpha-lactalbumin should also be investigated." 





Whey protein rich in alpha-lactalbumin increases the ratio of plasma tryptophan to the sum of the other large neutral amino acids and improves cognitive performance in stress-vulnerable subjects

2002 Jun;75(6):1051-6.



 "...  the results suggest that dietary protein rich in alpha-lactalbumin improves cognitive performance in stress-vulnerable subjects via increased brain tryptophan and serotonin activities." 





This brings to mind what was posted by SunshineFour in about the 4th post in the following thread. 

Lane Simonian
Posted: Thursday, December 27, 2012 12:49 PM
Joined: 12/12/2011
Posts: 4854

And yet another advantage to whey, it may increase glutathione levels: the body's master antioxidant, which is depleted in Alzheimer's disease. 


Higher glutathione levels will increase serotonin and acetylcholine levels and improve memory by scavenging peroxynitrites which damage serotonin and acetylcholine receptors. 

Posted: Sunday, December 30, 2012 4:20 PM
Joined: 12/21/2011
Posts: 62

Lexapro = escitalopram.


Check escitalopram and memory.