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Study Links Dementia and Lou Gehrig's Disease
Myriam
Posted: Wednesday, December 26, 2012 3:33 PM
Joined: 12/6/2011
Posts: 3326


(Source: jacksonville.com) - Researchers at Mayo Clinic have uncovered a toxic cellular process by which a protein that maintains the health of neurons becomes deficient and can lead to dementia. The findings shed new light on the link between culprits implicated in two devastating neurological diseases: frontotemporal dementia and amyotrophic lateral sclerosis, also known as Lou Gehrig's disease.


There is no cure for frontotemporal dementia, a disorder that affects personality, behavior and language and is second only to Alzheimer's disease as the most common form of early-onset dementia. While much research is devoted to understanding the role of each defective protein in these diseases, the team took a new approach to examine the interplay between TDP-43, a protein that regulates messenger ribonucleic acid (mRNA) - biological molecules that carry the information of genes and are used by cells to guide protein synthesis - and sortilin, which regulates the protein progranulin.

 

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