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any trials or research for late stage?
galfromiowa
Posted: Sunday, March 23, 2014 8:44 AM
Joined: 11/23/2013
Posts: 309


My dh does not qualify for any trials that I have found due to his late stage. I am mainly concerned with using this as a way to help fight the war on ad itself. I realize that it probably would help him, but hopefully lead to some discovery that could help future generations. Any ideas?
Myriam
Posted: Sunday, March 23, 2014 1:15 PM
Joined: 12/6/2011
Posts: 3326


Below is an article just released and it appears pharma is only targeting early and mid stage. However, if you aren't already trying "best practices" and aroma therapy (see Lane's postings), it would be interesting to see if you see improvement.

 

As you may know, Best Practices include:

Eating a mediterranean Diet

Strenuous exercise

Staying socially active

Taking memory meds as directive

Aroma therapy

 

 http://onlinelibrary.wiley.com/doi/10.1111/joim.12191/abstract 


Biff Calhoun
Posted: Sunday, March 23, 2014 1:58 PM
Joined: 8/20/2013
Posts: 56


Since numerous clinical trials attempting to treat AD have "blown up," sadly, it appears many researchers have thrown in the towel on finding a cure and are now shifting focus to early stage [MCI] and prevention.  Studies like the A4 are trying to stop the progression at the earliest on-set stage when less damage has been done.  Anything that eventually works with that subset MIGHT work with advanced stage people and act to arrest the progression.  But what good is it to just stop the progression at say, MMSE =15 or less?  To turn the corner and improve cognitive function I suspect we are going to need some form of neurogenisis or recreation of the neurons.  There is some work in this field, but not enough.

 

So there are a few things one can do to support natural neurogensis.  Yeah, I know - we all are taught in biology class that neurons don't regenerate.  But in fact, research shows there are some natural processes that do regenerate neurons.

 

One of those processes is in fact, the strenuous exercise mentioned in the "standard" things one can do.  So make sure that exercise gets implemented. 

 

 Second, studies suggest that caloric deprevation is another catalyst for neurogensis.  I can't imagine that many people are willing to drop their food intake to the levels needed, nor that this would be advisable with this condition, but it is a method.  [Note: some engineer has developed a one shake drink that apparently contains ALL of the FDA noted macro & micro-nutrients.  The stuff is called soylent and should be commercially available in a few months.  https://campaign.soylent.me/soylent-free-your-body ]

 

Third, something that I would add to the list of items is STRENUOUS MENTAL EXERCISE!  Now I do not mean working the crossword puzzle if that is what one has always done.  No, those pathways in the brain are well traveled and like a path in the woods, they are clear and open.  What needs to be done is to work the pathways less traveled such that they do not grow over. 

 

 So that means doing other kinds of puzzles, games or exercises to work other (all) parts of the brain.  Many might think that "reading" is a good mental exercise - it isn't as the words and meaning can "wash" over the person and not really sink in.  Better is to read something, then put it aside and either have a discussion with someone about what was read OR write a "book report" on what was read.  The combination of INPUT (reading) and OUTPUT (talking/writing) exercises the brain. 

 

 There are some online cognitive training games one can do for a fee or free (lumosity.com) but I suspect that if the patient is well advanced these would be frustrating and unhelpful.  The thing that several neurologists have suggested is trying to learn another language as great mental exercise! 

 

 Now the tough reality of it - one needs to work their brain to a point of "failure" - meaning challenge it so much that one reaches the edge where the patient is going to fail.  I know this is something that no one wants to do, as we want to be kind and gentle with those battling AD, but neurologists point out that this is the only way to know one is working the brain hard enough and really doing the "exercises" that work those other pathways.

 

Then there are possible "drugs" out there that can boost neurogensis.  See my long-ish post here:

http://www.alzconnected.org/discussion.aspx?g=posts&t=2147504662

 

Good luck and best wishes!

 

 

 

ps - can supply some references if anyone is interested - just say which ones...



Lane Simonian
Posted: Sunday, March 23, 2014 3:42 PM
Joined: 12/12/2011
Posts: 4986


Good information in this thread.  Here is further evidence that a particular diet can promote neurogenesis in the hippocampus (aromatherapy is not mentioned but several essential oils contain high levels of phenolic compounds).

 
Polyphenols and polyunsaturated fatty acids boost the birth of new neurons New neurons generated in the olfactory bulb by LMN diet (brown colour)23.11.2009  RESEARCH   -   UAB researchers have confirmed that a diet rich in polyphenols and polyunsaturated fatty acids, patented as an LMN diet, helps boost the production of the brain's stem cells -neurogenesis- and strengthens their differentiation in different types of neuron cells. The research revealed that mice fed an LMN diet, when compared to those fed a control diet, have more cell proliferation in the two areas of the brain where neurogenesis is produced, the olfactory bulb and the hippocampus, both of which are greatly damaged in patients with Alzheimer's disease. These results give support to the hypothesis that a diet made up of foods rich in these antioxidant substances could delay the onset of this disease or even slow down its evolution. 

The study will be published in the December issue of the Journal of Alzheimer's Disease and was directed by Mercedes Unzeta, professor of the UAB Department of Biochemistry and Molecular Biology. Participating in the study were researchers from this department and from the departments of Cell Biology, Physiology and Immunology, and of Psychiatry and Legal Medicine, all of which are affiliated centres of the Institute of Neuroscience of Universitat Autònoma de Barcelona. The company La Morella Nuts from Reus and the "Fundació ACE. Institut Català de Neurociències Aplicades" also collaborated in the study.

 

Polyphenols can be found in tea, beer, grapes, wine, olive oil, cocoa, nuts and other fruits and vegetables. Polyunsaturated fatty acids can be found in blue fish and vegetables such as corn, soya beans, sunflowers and pumpkins. The LMN cream used in this study was composed of a mixture of natural products: dried fruits and nuts, cocoa, vegetable oils rich in polyunsaturated fat and flour rich in soluble fiber. These creams were created and patented by La Morella Nuts, located in Reus near Tarragona. Previous studies had verified their effects on regulating cholesterol levels and hypertension, two risk factors commonly associated with heart disease and Alzheimer's disease.

 

During the development of the brain, stem cells generate different neural cells (neurons, astrocytes and oligodendrocytes) which end up forming the adult brain. Until the 1960s it was thought that the amount of neurons in adult mammals decreased with age and that the body was not able to renew these cells. Now it is known that new neurons are formed in the adult brain. This generative capacity of the cells however is limited to two areas of the brain: the olfactory bulb and the hippocampus (area related to the memory and to cognitive processes). Although the rhythm of cell proliferation decreases with age and with neurodegenerative diseases, it is known that exercise and personal well being can combat this process. 


 

The main objective of this research was to study the effect of an LMN cream-enriched diet on the neurogenesis of the brain of an adult mouse. Scientists used two groups of mice for the study. One group was given a normal diet and the other was given the same diet enriched with LMN cream. Both groups were fed during 40 days (approximately five years in humans). The analyses carried out in different brain regions demonstrated that those fed with LMN cream had a significantly higher amount of stem cells, as well as new differentiated cells, in the olfactory bulb and hippocampus.

 

The second objective was to verify if the LMN cream could prevent damage caused by oxidation or neural death in cell cultures. Cultures of the hippocampal and cortical cells were pretreated with LMN cream. After causing oxidative damage with hydrogen peroxide, which killed 40% of the cells, scientists observed that a pretreatment with LMN cream was capable of diminishing, and in some cases completely preventing, oxidative damage. The hippocampal and cortical cells were also damaged using amyloid beta (anomalous deposits of this protein are related to Alzheimer's disease). The results obtained were similar to those obtained using hydrogen peroxide.

 

These results demonstrate that an LMN diet is capable of inducing the generation of new cells in the adult brain, and of strengthening the neural networks which become affected with age and in neurogenerative processes such as Alzheimer's disease, as well as protecting neurons from oxidative and neural damage, two phenomena which occur at the origin of many diseases affecting the central nervous system.

 

In this study researchers have used different biochemical and molecular analysis techniques, with the help of specific antibodies, to detect different neuronal markers implied in the process of differentiation.

 

The group of researchers led by Dr Unzeta has spent years studying the effects oxidases have on oxidative stress as a factor implied in neurodegenerative disorders such as Parkinson and Alzheimer's disease, and the effects of different natural products with anti-inflammatory and antioxidant properties in different experimental models of Alzheimer's disease.

 

The study forms part of the CENIT project, which was awarded to La Morella Nuts in 2006 under the auspices of the INGENIO 2010 programme, with the objective of establishing methodologies for the design, evaluation and verification of functional foods which may protect against cardiovascular diseases and Alzheimer's disease. With 21.15m euros in funding and a duration of four years, the project has included the participation of 50 doctors and technicians from nine different companies, four universities (7 departments) and 2 research centres.

 

La Morella Nuts, located in Reus, Tarragona, Spain, specialises in manufacturing products for confectionery makers in which the main ingredients are dried fruits and nuts - creams, pastry, pralines, etc. - and cocoa. Since 1994 the company has worked on several R&D&I projects in collaboration with universities, research centres and other businesses, and has patented different products resulting from these research projects.

 

Image: New neurons generated in the olfactory bulb by LMN diet (brown colour).

 

Reference article: "A diet enriched in polyphenols and polyunsaturated fatty acids, LMN diet, induces neurogenesis in the subventricular zone and hippocampus of adults mouse brain". Valente et al., 2009, Journal of Alzheimer’s Disease, Volume 18:4. Valente T., Hidalgo, J., Bolea, I., Ramírez B., Anglés, N., Reguant, J., Morelló, J.R., Gutiérrez, C., Boada, M., Unzeta, M.