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Ultrasound possible cure for Alzheimer's
HMW
Posted: Thursday, March 12, 2015 10:12 AM
Joined: 3/5/2015
Posts: 63


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Sci Transl Med
Vol. 7, Issue 278, p. 278ra33
Sci. Transl. Med. DOI: 10.1126/scitranslmed.aaa2512
  • Research Article
ALZHEIMER’S DISEASE

Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model

  1. Jürgen Götz*

+ Author Affiliations

  1. Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, St Lucia Campus, Brisbane, Queensland 4072, Australia.
  1. *Corresponding author. E-mail: j.goetz@uq.edu.au

Abstract

Amyloid-β (Aβ) peptide has been implicated in the pathogenesis of Alzheimer’s disease (AD). We present a nonpharmacological approach for removing Aβ and restoring memory function in a mouse model of AD in which Aβ is deposited in the brain. We used repeated scanning ultrasound (SUS) treatments of the mouse brain to remove Aβ, without the need for any additional therapeutic agent such as anti-Aβ antibody. Spinning disk confocal microscopy and high-resolution three-dimensional reconstruction revealed extensive internalization of Aβ into the lysosomes of activated microglia in mouse brains subjected to SUS, with no concomitant increase observed in the number of microglia. Plaque burden was reduced in SUS-treated AD mice compared to sham-treated animals, and cleared plaques were observed in 75% of SUS-treated mice. Treated AD mice also displayed improved performance on three memory tasks: the Y-maze, the novel object recognition test, and the active place avoidance task. Our findings suggest that repeated SUS is useful for removing Aβ in the mouse brain without causing overt damage, and should be explored further as a noninvasive method with therapeutic potential in AD.


scma_2007
Posted: Thursday, March 12, 2015 11:02 AM
Joined: 9/13/2013
Posts: 112


Thank you for this post.

This is a novel treatment that is non-invasive and seems to be low risk. Hopefully, there will be further study to apply this in humans.



Tom(ek)
Posted: Monday, March 23, 2015 7:37 AM
Joined: 12/21/2011
Posts: 62


Australian researchers have come up with a non-invasive ultrasound technology that clears the brain of neurotoxic amyloid plaques - structures that are responsible for memory loss and a decline in cognitive function in Alzheimer’s patients.

/.../

Publishing in Science Translational Medicine, the team describes the technique as using a particular type of ultrasound called a focused therapeutic ultrasound, which non-invasively beams sound waves into the brain tissue. By oscillating super-fast, these sound waves are able to gently open up the blood-brain barrier, which is a layer that protects the brain against bacteria, and stimulate the brain’s microglial cells to activate. Microglila cells are basically waste-removal cells, so they’re able to clear out the toxic beta-amyloid clumps that are responsible for the worst symptoms of Alzheimer’s.

The team reports fully restoring the memories of 75 percent of the mice they tested it on, with zero damage to the surrounding brain tissue. They found that the treated mice displayed improved performance in three memory tasks - a maze, a test to get them to recognise new objects, and one to get them to remember the places they should avoid.

/.../

The team says they’re planning on starting trials with higher animal models, such as sheep, and hope to get their human trials underway in 2017.

http://www.sciencealert.com/new-alzheimer-s-treatment-fully-restores-memory-function

http://stm.sciencemag.org/content/7/278/278ra33

http://www.abc.net.au/radio/programitem/peOWD0e2P3?play=true