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Leukine, a repositioned drug, could be promising, BUT...
JackX
Posted: Monday, March 6, 2017 6:20 PM
Joined: 12/20/2016
Posts: 100


A repositioned drug Leukine (a bone marrow transplants patient drug) is under study. It is promising in:

1) It is a "most effective amyloid or plaque reducing molecule anyone has ever seen";

2) "The drug removed the plaque without causing other significant damage."

The only problem is that it carries a price tag $100,000.00 per year.

http://www.9news.com/life/senior-source/a-promising-new-treatment-for-alzheimers/413966523

 


JackX
Posted: Friday, May 19, 2017 12:30 PM
Joined: 12/20/2016
Posts: 100


More news on Leukine:

http://www.9news.com/life/senior-source/the-link-between-alzheimers-and-down-syndrome/440858655

"...inflamed joints in an arthritis patient are apparently generating, among other things, lots of naturally occurring Leukine."

See also:

http://www.alz.org/research/alzheimers_grants/for_researchers/overview-2016.asp?grants=2016potter

 


JackX
Posted: Wednesday, July 19, 2017 8:00 PM
Joined: 12/20/2016
Posts: 100


More test results on Leukine reported:

http://www.9news.com/news/health/co-doctors-find-prelim-results-positive-in-early-tests-of-alzheimers-drug/457955966

From the report:

Essentially, the first safety trials for Leukine involved 32 people with the disease.

13 were injected with the drug itself. 19 others received a placebo, or, just plain salt water.

The results were surprisingly positive.

"Compared to their starting place, the people who received Leukine actually improved in their cognition, as measured by the MMSE, which is the Mini Mental State Exam," said Potter. And the people who received the salt water placebo stayed the same. So that means that at the end of treatment there was a big difference between the people who received Leukine and the people who received placebo."

Further, the patients who did improve did so quickly. They were showing results in just a matter of three weeks, after only some 15 injections.

"Alzheimer's disease takes probably decades before it even starts to present the first signs of having any cognitive impairment," said researcher Dr. Timothy Boyd. "So to improve cognition within only 15 days of an injection of a treatment--that is very astonishing."

And even more remarkable is that within that same period of time, the Leukine patients actually began to show some improvement in day to day activity, able to once again do things that the disease had taken from them.

Dr. Potter refers to that as being "cautiously very positive."

 


Larrytherunner
Posted: Friday, July 21, 2017 11:45 AM
Joined: 2/26/2016
Posts: 242


Jack. As you may have noticed, all of the beta amyloid reducing drugs in clinical trials have failed so far, and recent research is pointing toward Alzheimer's as caused by an overactive brain immune system. From what I have read, Leukine may also affect the immune system.

 

Even if the trials prove succeessful in the next two years, it would be a long time before medicare and the insurance companies would agree to pay for this expensive treatment, which you said is over $100,000 a year.

 

I would suggest you try the asthma drug montelukast. The brand name is Singulair. It works by blocking the inflammatory cysteinyl leukotrienes in the brain, thus reducing brain inflammation. I take one 10 mg tablet twice a day. One tablet is about 2 dollars. 

 

The Canadian pharmaceutical company Intelgenx is sponsoring montelukast in clinical trials for Alzheimer's and dementia, under the supervision of the Canadian government. Results should be available sometime next year. 

 

I am 69 years old and have been taking this drug for more than 16 months. Before taking this drug, I was experiencing extreme mental fatigue and occasional confusion. Within a week after starting this drug, I was back to normal. I have had no bad side effects. Also I have noticed that I do sleep much better than before.

 

This is an extremely safe drug, used by millions and safer than aspirin for long term use. You can try it for a couple of weeks. If it reduces brain inflammation, you will definitely feel better, and it may also slow down the progression of the disease. 

 

I am attaching a summary by Dr Spencer Rozin MD in Lawrenceville, GA, which shows case studies of 17 patients with various stages of dementia treated with montelukast. Sixteen patients showed improvement, which is 94 percent of the patients. The summary was republished by the National Institute of Health (NIH) in January 2017.

 

Let us know the outcome if you should decide to try it.

 

Dr S Rozin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420184/

 

Dr Rozin's website http://www.drrozin.com/

 

 


JackX
Posted: Friday, July 21, 2017 1:57 PM
Joined: 12/20/2016
Posts: 100


"Jack. As you may have noticed, all of the beta amyloid reducing drugs in clinical trials have failed so far,"

I am sorry, did I miss something, such as some "nobody-prize" winner had proved that beta amyloid has no roles in Alzheimer's.