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Question regarding medication
Jimmyo
Posted: Saturday, March 9, 2019 9:42 AM
Joined: 3/8/2019
Posts: 4


 Just a question regarding medication.

DW diagnosed about 2 years ago with dementia and is currently taking 50mg of Memantine, twice daily & 10mg of Donepezil once daily. She seem to be slipping back to where she once was prior to medication.

Wondering if dosage can be increased or if anyother medication would help.

Thank You, 


Lane Simonian
Posted: Saturday, March 9, 2019 10:46 AM
Joined: 12/12/2011
Posts: 4982


Welcome Jimmyo.  Aricept only temporarily slows down the early progression of Alzheimer's disease.  The same is also likely true for memantine during the middle to later stages of the disease (one controversial study even suggested that memantine made the disease worse).  

https://www.drperlmutter.com/alzheimers-drugs-worsen-cognitive-function/

There are no other prescribed medications that effectively treat Alzheimer's disease.  Small-scale studies using various essential oils through aromatherapy (direct inhalation is probably better than a diffuser), panax ginseng, and CBD oil suggest that they may help in the treatment of Alzheimer's disease.

https://onlinelibrary.wiley.com/doi/full/10.1111/j.1479-8301.2009.00299.x

https://www.ncbi.nlm.nih.gov/pubmed/22780999

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659550/

https://www.ncbi.nlm.nih.gov/pubmed/26757043

I wish the best for you and for your wife.



Jimmyo
Posted: Monday, March 11, 2019 8:42 AM
Joined: 3/8/2019
Posts: 4


Thank you very much for your reply.

 


Llewis
Posted: Monday, March 11, 2019 9:59 AM
Joined: 2/9/2019
Posts: 13


Jimmy;

Just another option but might be worth looking into the Anavex study they have enrolling right now. New approach but she has to fit in the criteria required. I asked on here a while ago if anyone had enrolled and got no response but they may be now? See my previous post and Lane's response. He could fill you in on the science. Both he and I feel pretty optimistic about the drug. Good luck with whatever you try.


Lane Simonian
Posted: Wednesday, March 13, 2019 1:54 PM
Joined: 12/12/2011
Posts: 4982


You are welcome, Jimmy.

The Anavex 2-73 phase 2b/3 trial is taking place in Australia, with North American sites to be added.

https://www.anavex.com/anavex-life-sciences-receives-approval-to-initiate-phase-2b-3-clinical-trial-of-anavex2-73-for-the-treatment-of-early-alzheimers-disease/

Like, Llewis, I am following this drug carefully.  I like the science behind it.  I keep trying to simplify the science.  I wrote this about Anavex 2-73 just recently:

Most of the interventions in Alzheimer’s disease slow down the progression of the disease by inhibiting particular points in the pathways that lead to oxidation, nitration, and neuronal cell death: removal of amyloid oligomers which decreases intracellular calcium release by lessening the activation of g protein-coupled receptors, inhibition of the release of intracellular calcium (Aricept), inhibition of protein kinase C activity (riluzole), and inhibition of NMDA receptor activity (Namenda/memantine).

The likely key to treating Alzheimer’s disease, though, is to not only inhibit the triggers, receptors, and enzymes that are behind the disease, but to remove peroxynitrite and to reverse part of its damaging effects. If all Anavex 2-73 does is inhibit intracellular calcium release better than Aricept it is still a better drug than Aricept. But if it also acts as an effective antioxidant, then it will do much more.

I hope good answers come soon.

 


Llewis
Posted: Thursday, March 14, 2019 9:12 AM
Joined: 2/9/2019
Posts: 13


Lane

In regard to Anavex PDD trial; do you read anything into the investigators asking to extend the trial, just as they did in the initial ALZ trial?

 Thank you.


EN85
Posted: Thursday, March 14, 2019 10:21 AM
Joined: 1/10/2019
Posts: 70


Hi Jimmyo, when I inquired about upping my mom's dosage her neurologist told me that he wouldn't because it doesn't usually help. I did get him to agree to write a script for Axona though however there was not a big change.
Lane Simonian
Posted: Thursday, March 14, 2019 10:54 AM
Joined: 12/12/2011
Posts: 4982


I am not in a position to verify it, but the speculation is that the caregivers and in some cases patients wanted the extensions and that regulators were also seeing some positive effects.  If one or both are true that is a good sign.


Lane Simonian
Posted: Thursday, March 14, 2019 10:56 AM
Joined: 12/12/2011
Posts: 4982


I don't see how upping the dose of Aricept and Memantine would help either.
Jimmyo
Posted: Saturday, March 16, 2019 6:20 AM
Joined: 3/8/2019
Posts: 4


Thank You!