Joined: 8/13/2019
Posts: 12
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https://www.alzforum.org/news/research-news/acetaminophen-derivative-tempers-microglia-spurs-plaque-clearance
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Joined: 2/17/2019
Posts: 380
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My sister heard something about acetaminophen and started taking one a day, until she got her test results.
It sounds very good, and yay for the mice. Now lets see about the humans.
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Joined: 12/12/2011
Posts: 4973
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This may be one more of those cases where a little bit may have some benefit but too much is harmful. The overuse of Acetaminophen via the production of peroxynitrite can contribute to liver damage and possibly brain damage.
In the brain, overdose of acetaminophen causes a dramatic decrease of glutathione levels, ascorbic acid levels and superoxide dismutase activity (Nencini et al., 2007).
The above documented toxic effects associated with oxidative stress are elicited in response to high doses of acetaminophen. However, several studies have indirectly demonstrated acetaminophen’s capacity to function as an antioxidant. During post-ischemia-reperfusion in the heart acetaminophen attenuates the damaging effects of peroxynitrite and hydrogen peroxide and limits protein oxidation (Merrill and Golberg, 2001; Jaques-Robinson et al., 2008).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818055/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912877/
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