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A Biomarker-directed Study of XPro1595 in Patients With Mild to Moderate Alzheimer's
wolfewoman
Posted: Monday, March 1, 2021 4:28 PM
Joined: 1/1/2018
Posts: 209


I found this on Clinical Trials.gov  Sorry I don't know how to link the entire article

I think the second trial is underway, also in Austrailia.

The study is designed as a multicentre, phase 1b open-label study. The objectives of this study are to determine the safety, tolerability, and efficacy of XPro1595 in patients with mild to moderate Alzheimer's disease and elevated blood levels of the inflammatory biomarker high sensitivity c-reactive protein (hs-CRP).

XPro1595 is a second-generation inhibitor of tumor necrosis factor (TNF) that selectively neutralizes soluble TNF, an inflammatory factor implicated in Alzheimer's pathology.

A key element of this study is to identify Alzheimer's patients that are most likely to benefit from XPro1595 treatment. Enrollment is limited to patients with evidence of peripheral inflammation using elevated blood inflammatory biomarkers. For instance, hs-CRP is an inflammatory biomarker elevated in the blood of some Alzheimer's patients and elevated CRP has been shown to predict response to TNF inhibitors in multiple other diseases.

Alzheimer's patients with elevated blood inflammatory biomarkers will be enrolled in a 12-week study to determine the safety and the ability of XPro1595 to reduce neuroinflammation using a combination of invasive and non-invasive biomarkers of inflammation. The study will identify the dose of XPro1595 to be used in a larger Phase II disease modification study.


Msteele
Posted: Saturday, March 6, 2021 6:19 AM
Joined: 3/6/2021
Posts: 1


I believe this is the URL you were referring to.  Thanks for the lead.  
clinicaltrials.gov/ct2/show/NCT03943264