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Cerebrospinal Fluid Biomarkers
Posted: Thursday, January 12, 2012 1:51 PM
Joined: 12/6/2011
Posts: 3326

(Source: Alzheimer Research Forum) - The longest study yet to correlate Alzheimer's biomarkers in cerebrospinal fluid (CSF) with disease progression confirms that B amyloid levels bottom out at pathological levels up to 10 years before the clinical onset of disease. In contrast, CSF tau levels are higher the closer people are to developing dementia, implying that tau continues to rise as cognitive impairment progresses, report researchers led by Oskar Hansson at Skåne University Hospital, Sweden. The data lend further support to current models of biomarker progression. The authors also note that the ratio of B amyloid to phosphorylated tau in the CSF can predict with high accuracy which people will progress from mild cognitive impairment (MCI) to AD, making this biomarker potentially useful for selecting participants in clinical trials.

"Not only do [the data] support the proposed trajectory of specific biomarker changes very early in the course of the disease, but they also provide support for the importance of assigning an underlying etiology to the construct of MCI," Anne Fagan at Washington University School of Medicine wrote, noting that MCI with AD biomarkers should be considered early AD. "I predict that longer clinical follow-up in cognitively normal individuals who exhibit AD biomarker profiles will provide support for the utility of such biomarkers to identify individuals with the disease even earlier, before the onset of any clinical symptoms."

Hansson is currently developing methods to detect AB oligomers in CSF, as oligomers are widely believed to be the neuro-toxic form of AB. Hansson will investigate whether adding CSF oligomer levels to the equation will improve diagnostic accuracy. Monitoring changes in CSF oligomers might also provide a way to assess the effectiveness of anti-amyloid therapies, Hansson reported.

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Posted: Thursday, January 12, 2012 4:46 PM
Joined: 12/8/2011
Posts: 33

Thanks for this Myriam!