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"Fruitflow" (tomato extract) may improve memory? (clinical trial)
onward
Posted: Friday, March 29, 2013 10:30 AM
Joined: 12/20/2011
Posts: 217


 

 

In one of Myriam's recent posts -
 http://www.alzconnected.org/discussion.aspx?g=posts&t=2147496456 
- I noticed a clinical trial exploring something called Fruitflow-II for people with MCI / memory problems.  Hadn't heard of this before so did a bit of research.
 

  

Has anyone here tried fruitflow or heard of others who have? 

   

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Here's the clinical trial:
 
 

Cerebrovascular and Cognitive Improvement by Resveratrol (resVida) and Fruitflow-II (CCIRF-II)

  

This study is currently recruiting participants.  

  

  

  

The purpose of this study is to determine whether Fruitflow-II, Resveratrol (resVida), alone or in combination, are effective in the treatment of memory problems in adult patients with memory impairment. We also evaluate effects of these medications on blood flow to the brain and fitness, to find whether the possible improvement in memory is associated with the alterations in these parameters. 

  

... Accumulating evidence suggests that tomato consumption has cardiovascular benefits, primarily through increasing blood flow in vivo; the active ingredient in tomato, or its extract (Fruitflow) have been shown to inhibit glycoprotein IIb/IIIa, similar to aspirin (which has antiplatelet activity and is used for secondary prevention of cardiovascular and cerebrovascular events in patients). Considering the fact that Fruitflow can improve the platelet function and peripheral blood flow, we hypothesized that Fruitflow can also increase the blood flow in the brain and thereby possibly enhance memory and cognitive function in middle-aged or elderly people who have memory complaints...  

  

  

Much more here: http://www.clinicaltrials.gov/ct/show/NCT01766180  

  

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The fruitflow being used in the clinical trial is described as "Fruitflow-II" "supplied in capsules which contain 150 mg active ingredient."  Since "DSM Nutritional Products, Inc." is said to be a collaborator in the trial, I'm assuming that's the brand of Fruitflow being used.

Here are the claims being made by DSM for "Fruitflow":


What is Fruitflow®

Fruitflow® is a breakthrough ingredient – the first natural, scientifically substantiated solution contributing to healthy blood flow. In ten human trials, consumption of Fruitflow® has been proven to maintain healthy platelet aggregation and improve blood flow. The effect takes place within 1.5 hours and lasts for 12 to 18 hours. When taken regulary on a once per day basis, the effect is continuous, making it ideal for use in functional foods or dietary supplements.

Efficacy and safety

Fruitflow® was discovered by Professor Asim Duttaroy at the Rowett Research Institute in Aberdeen in 1999. Since then, Fruitflow’s effectiveness has been tested in ten different studies on healthy volunteers.

• Healthy platelet aggregation was maintained; platelets became less activated or ‘smoother’ after consuming a food, beverage or dietary supplement containing Fruitflow®.
• Effective in 97% of subjects tested in published studies.
• Safety has also been confirmed in multiple human studies.
• No side effects have been reported; no adverse effects from prolonged intake, no allergic reactions and, no increased bleeding risk for people who take blood- thinning agents.

Claims

Fruitflow’s strong science has been evaluated by the European Food Safety Authority and granted the first approved article 13.5 (proprietary) health claim: “Fruitflow® helps maintain normal platelet aggregation, which contributes to healthy blood flow.”

Depending on the local regulatory requirements and interpretation, claim
wording might be modified.

Composition

Fruitflow® is a water-soluble, tomato-based concentrate developed in two variant forms named Fruitflow® I (water-soluble syrup) and its sugar-free derivative Fruitflow® II, supplied in powder format. These two products are prepared from tomato extract using patented processes and are intended for use as nutritional ingredients for food, beverages and dietary supplements. Chemical specifications of the active constituents are provided and batch to batch reproducibility has been demonstrated. Both Fruitflow® forms are standardized on 3 bioactive fractions.

Applications and dosage

Fruitflow® I performs well in most food and beverage applications, such as juice-based and water-based beverages, as well as dairy applications with a recommended dosage of 3 grams.

Fruitflow® II is being developed for use in dietary supplements, with a recommended dosage of 150 mg.



 
http://www.dsm.com/en_US/foodandbeverages/public/home/pages/prod-fruitflow.jsp

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DSM Fruitflow is an ingredient in "Langer's Tomato Juice Plus" and "L&A Tomato Juice." 

 http://www.bloomberg.com/article/2012-10-10/asiZeclxF6a4.html
 
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In the UK, fruitflow is found in Sirco fruit juices:

http://news.cision.com/ccd-healthcare-pr/r/sirco--the-natural-alternative-to-aspirin-wihout-the-side-effects,c476686  


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Another fruitflow product I came across is a liquid called OptiFlow, sold at brickerlabs.com .
 

   

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Fruitflow is also sold in capsules.  Swanson markets a fruitflow capsule available at amazon.com and elsewhere.

 

 

 

 

 

 

 

 

 

 


Lane Simonian
Posted: Friday, March 29, 2013 11:43 AM
Joined: 12/12/2011
Posts: 5107


Whenever I see your posts Onward (and Myriam's), I get excited because I know that I am going to read something important, exciting, and potentially groundbreaking.   

 

These two studies are particularly useful in explaining why lycopene (a key ingredient in tomatoes) may be useful in the prevention and treatment of Alzheimer's disease. 

 

2005 Oct;146(4):216-26.

Inhibitory effects of lycopene on in vitro platelet activation and in vivo prevention of thrombus formation.

Source

Graduate Institute of Pharmacology, Taipei Medical University, Taipei, Taiwan.

Abstract

Lycopene is a natural carotenoid antioxidant that is present in tomatoes and tomato products. The pharmacologic function of lycopene in platelets is not yet understood. Therefore, in this study we sought to systematically examine the effects of lycopene in the prevention of platelet aggregation and thrombus formation. We found that lycopene concentration-dependently (2-12 micromol/L) inhibited platelet aggregation in human platelets stimulated by agonists. Lycopene (6 and 12 micromol/L) inhibited phosphoinositide breakdown in platelets labeled with tritiated inositol, intracellular Ca+2 mobilization in Fura-2 AM-loaded platelets, and thromboxane B2 formation stimulated by collagen. In addition, lycopene (6 and 12 micromol/L) significantly increased the formations of cyclic GMP and nitrate but not cyclic AMP in human platelets. Rapid phosphorylation of a protein of 47,000 Da (P47), a marker of protein kinase C activation, was triggered by PDBu (60 nmol/L). This phosphorylation was markedly inhibited by lycopene (12 micromol/L) in phosphorus-32-labeled platelets. In an in vivo study, thrombus formation was induced by irradiation of mesenteric venules in mice pretreated with fluorescein sodium. Lycopene (5, 10, and 20 mg/kg) significantly prolonged the latency period for the induction of platelet-plug formation in mesenteric venules. These results indicate that the antiplatelet activity of lycopene may involve the following pathways: (1) Lycopene may inhibit the activation of phospholipase C, followed by inhibition of phosphoinositide breakdown and thromboxane B2 formation, thereby leading to inhibition of intracellular Ca+2 mobilization. (2) Lycopene also activated the formations of cyclic GMP/nitrate in human platelets, resulting in the inhibition of platelet aggregation. The results may imply that tomato-based foods are especially beneficial in the prevention of platelet aggregation and thrombosis.

 

 

2006 Sep 15;215(3):330-40. Epub 2006 May 2.

Effect of lycopene and beta-carotene on peroxynitrite-mediated cellular modifications.

Source

Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.

Abstract

Peroxynitrite formed by the reaction of superoxide and nitric oxide is a highly reactive species with a role in various pathological processes such as cancer, chronic inflammation, and cardiovascular and neurological diseases. In the present study, the effect of the carotenoids, lycopene and beta-carotene, on peroxynitrite-mediated modifications in plasmid DNA as well as cellular DNA and proteins were investigated. In pUC18 plasmid DNA, these carotenoids strongly inhibited DNA strand breaks caused by peroxynitrite generated from 3-morpholinosydnonimine (SIN-1). SIN-1 was also used to determine effects on DNA damage and protein tyrosine nitration in Chinese hamster lung fibroblasts. SIN-1 dose-dependently increased nitration of proteins in cells above basal levels as determined by Western blotting. This nitration was inhibited in the presence of the uric acid as well as lycopene. Physiological concentrations (0.31-10 microM) of lycopene and beta-carotene also had protective effects on DNA damage, as measured by the comet assay. Lycopene significantly reduced DNA damage particularly, in the median range of concentrations (2.5 microM). The protective effects of lycopene and beta-carotene could be due to their scavenging of reactive oxygen (ROS) and/or nitrogen species (RNS) as they reduce the amount of intracellular ROS/RNS produced following treatment with SIN-1 by as much as 47.5% and 42.4%, respectively. The results obtained in this study suggest that carotenoids may alleviate some of the deleterious effects of peroxynitrite and possibly other reactive nitrogen species as well in vivo.

 

 

Lycopene inhibits phospholipase C which leads to amyloid plaques (phospholipase C--intracellular calcium release), peroxynitrites (phospholipase C--Protein kinase C--p38 MAPK--peroxynitrites), and platelet aggregation and it either scavenges peroxynitrites or one of its building blocks--superoxide anions.   

 

And a small bit of evidence for the protective effects of lycopene against Alzheimer's disease. 

 

Lycopene may help to prevent Alzheimer's Disease [epidemiological evidence: persons who consume higher levels of Lycopene have a lower incidence of Alzheimer's Disease].