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Prostate cancer tx doubles risk for AD
llee08032
Posted: Tuesday, December 8, 2015 10:15 AM
Joined: 5/20/2014
Posts: 4408


Common Prostate Cancer Treatment May Double Risk for Alzheimer's

I wonder if testosterone plays a role in protecting men from AD? Also if women with AD could benefit from testosterone? 


llee08032
Posted: Wednesday, December 9, 2015 7:56 AM
Joined: 5/20/2014
Posts: 4408


From what I can understand of this news report, the treatment for prostate ca decreases testosterone and therefore increases the risk for AD. Since more women than men are dx with AD I'm curious if there is a connection related to testosterone? 
Lane Simonian
Posted: Wednesday, December 9, 2015 10:49 AM
Joined: 12/12/2011
Posts: 5107


Testosterone is another curious example of what protects your brain under conditions of low oxidative stress harms it under conditions of high oxidative stress (at least in Caucasian males).

While testosterone may be beneficial under conditions of low oxidative stress, testosterone appears to have negative consequences under conditions of elevated oxidative stress, but only in Caucasians. Mexican-Americans, however, were protected from any deleterious effects of testosterone, potentially due to higher levels of endogenous antioxidant defenses...

http://www.ncbi.nlm.nih.gov/pubmed/24496073

This is yet another piece of evidence that Alzheimer's disease is caused by oxidative stress and that the key to treating the disease is with antioxidants (such as aromatherapy, panax ginseng, curcumin, melatonin, B-12 vitamins, a Mediterranean diet, etc.).  The only piece of the puzzle now missing is which antioxidants and in what combinations.


Lane Simonian
Posted: Wednesday, December 9, 2015 10:56 AM
Joined: 12/12/2011
Posts: 5107


I tried to find a good definition of oxidative stress.  Here is a fairly good one:

Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage.

And here is a good definition of how antioxidants work against diseases caused by peroxynitrite such as Alzheimer's disease.

The inflammatory mediator peroxynitrite, when generated in excess, may damage cells by oxidizing and nitrating cellular components. Defense against this reactive species may be at the level of prevention of the formation of peroxynitrite, at the level of interception, or at the level of repair of damage caused by peroxynitrite. Several selenocompounds serve this purpose and include selenoproteins such as glutathione peroxidase (GPx), selenoprotein P and thioredoxin reductase, or low-molecular-weight substances such as ebselen. Further, flavonoids, such as (-)-epicatechin, which occurs in green tea or cocoa as monomer or in the form of oligomers, can contribute to cellular defense against peroxynitrite.
Defenses against peroxynitrite: Selenocompounds and flavonoids (PDF Download Available). Available from: https://www.researchgate.net/publication/10822098_Defenses_against_peroxynitrite_Selenocompounds_and_flavonoids [accessed Dec 9, 2015].


llee08032
Posted: Wednesday, December 9, 2015 8:58 PM
Joined: 5/20/2014
Posts: 4408


Thanks Lane!
Lane Simonian
Posted: Thursday, December 10, 2015 12:36 AM
Joined: 12/12/2011
Posts: 5107


You are welcome, llee.  I take each ones of these studies as a type of clue that leads eventually to the effective treatment of Alzheimer's disease or other forms of dementia. Myriam used to post them all the time, but I am glad that you and others are posting them now.
Luceyka
Posted: Saturday, December 12, 2020 5:16 AM
Joined: 7/25/2020
Posts: 5


Prostate massage is a way to empty fluids from your prostate ducts. This therapy might offer some health benefits, or your doctor might use it to diagnose a problem. But it’s not something doctors usually recommend or use for testing or treatment.

The prostate is a small gland about the size of a golf ball between the base of the penis and the rectum. Its main job is to make the fluid, also called semen, that helps sperm travel and survive.

Massaging the prostate empties that fluid out of your prostate ducts. To do the procedure, your doctor will slide a gloved finger into your rectum, then massage or press on the prostate from there.

It may feel slightly uncomfortable, but it doesn’t take long. Although studies are limited, prostate massage may be helpful in some medical situations and with some health conditions.

Prostatitis is swelling and inflammation of the prostate gland. It can cause symptoms like pain when you pee and pain around your groin and pelvis. A doctor might do a prostate massage to diagnose the condition.

He can test the fluid that comes from your prostate ducts to see what’s causing the problem. Although the most common treatments for prostatitis are antibiotics and non-steroidal anti inflammatory drugs (NSAIDs), prostate massage is another option.

It can help ease pressure and swelling by releasing fluids that build up in the prostate. Small studies have found that massaging the area several times a week along with taking antibiotics can give relief from pain and pressure.

Sometimes a doctor might do a prostate massage during a prostate exam. The purpose is to get some fluid to examine under a microscope to look for signs of an infection or other problem.

The main treatments for erectile dysfunction include medications, pumps, shots, and implants. Lifestyle changes that can help treat the condition include getting more exercise, eating a healthy diet, and doing pelvic floor exercises.


If we are talking about testosterone level take a look at https://wemailmd.com/generic-androgel-testosterone/


Jo C.
Posted: Saturday, December 12, 2020 6:42 PM
Joined: 12/9/2011
Posts: 13113


This is a very old Thread from the year, 2015.  Please do not attempt to perform any such procedure on oneself or on a Loved One; this is not for casual or inexperienced individuals and has the potential for negative outcomes.

As said; old Thread.

J.