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Finally, a Tau focused treatment Trial
HowDoYouDeal
Posted: Monday, March 2, 2020 3:27 PM
Joined: 2/17/2019
Posts: 315


Detailed Description

RO7105705 is an anti-tau antibody that targets a protein involved in the progression of Alzheimer's disease.

 

 Participants will be randomly assigned to either the study treatment or placebo. Researchers will measure changes in severity of dementia symptoms and cognitive function, as well as any adverse events and concentrations of the drug at different timepoints.

 

https://www.nia.nih.gov/alzheimers/clinical-trials/ro7105705-moderate-alzheimers-disease


A Phase 2 trial is enrolling patients with moderate Alzheimer’s to test an investigational antibody known as RO7105705 that targets the Tau protein. The Genentech-sponsored multicenter, randomized study (NCT03828747) intends to assess the efficacy, safety, and pharmacological profile of RO7105705. The company plans to recruit 260 patients in the U.S. More information on study locations and contacts can be found here. After a screening period, patients will receive RO7105705 or placebo by intravenous infusion every two weeks for the first three doses and every four weeks thereafter in a double-blind treatment period. Participants can then undergo an optional open-label extension period which will consist of RO7105705 infusions every four weeks. The last stage will be a safety follow-up period. The trial's primary goal is measuring the change in cognitive function and functional abilities from baseline to week 49. RO7105705, or MTAU9937A, is being developed by Genentech — owned by Roche — and AC Immune. The treatment candidate is a humanized monoclonal antibody, designed to stop the cell-to-cell spread of toxic forms of the Tau protein in the brain. This spread is associated with the onset and progression of cognitive decline in Alzheimer’s disease. “Slowing the propagation of Tau
 
 
 
 
 

Locations

Name City State Zip Status Primary Contact Collaborative Neuroscience Network, Inc.
Garden Grove California 92845 Recruiting

Pharmacology Research Institute
Los Alamitos California 90720 Recruiting

Stanford University; Stanford Clinical Cancer Ctr
Palo Alto California 94305 Recruiting

Pacific Research Network - PRN
San Diego California 92103 Recruiting

Molecular Neuroimaging; MRI/PET
New Haven Connecticut 06510 Recruiting

KI Health Partners, LLC; New England Institute for Clinical Research
Stamford Connecticut 06905 Recruiting

JEM Research LLC
Atlantis Florida 33462 Recruiting

Bradenton Research Center
Bradenton Florida 34205 Recruiting

Brain Matters Research, Inc.
Delray Beach Florida 33445 Recruiting

Neuropsychiatric Research; Center of Southwest Florida
Fort Myers Florida 33912 Recruiting

Alzheimer's Research and Treatment Center
Lake Worth Florida 33449 Recruiting

Miami Jewish Health Systems
Miami Florida 33137 Recruiting

Collier Neurologic Specialists
Naples Florida 34105 Recruiting

Bioclinica Orlando
Orlando Florida 32806 Recruiting

Premiere Research Institute
West Palm Beach Florida 33407 Recruiting

Rush University Medical Center - Chicago
Chicago Illinois 60612 Recruiting

Alexian Brothers Neuroscience Institute
Elk Grove Village Illinois 60007 Recruiting

Southern Illinois University, School of Medicine
Springfield Illinois 62702 Recruiting

Brigham and Womens Hospital; Center for Alzheimer Research & Treatment
Boston Massachusetts 02115 Recruiting

Alzheimers Disease Center
Quincy Massachusetts 02169 Recruiting

Health Partners Center for Memory and Aging
Saint Paul Minnesota 55130 Recruiting

Advanced Memory Research Institute of NJ
Toms River New Jersey 08755 Recruiting

Empire Neurology PC; MS Center of Northeastern NY
Latham New York 12110 Active, not recruiting

University of Rochester; AD-CARE
Rochester New York 14642 Recruiting

Summit Research Network Inc.
Portland Oregon 97210 Recruiting

Abington Neurological Associates
Willow Grove Pennsylvania 19090 Recruiting

Rhode Island Mood & Memory Research Institute
East Providence Rhode Island 02914 Recruiting

Butler Hospital; Movement Disorders Program
Providence Rhode Island 02906 Recruiting

Neurology Clinic PC
Cordova Tennessee 38018 Recruiting

New Orleans Center for Clinical Research
Knoxville Tennessee 37920 Recruiting

The Memory Clinic
Bennington Vermont 05201 Active, not recruiting